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Flashcards in Innate to adaptive immunity Deck (27)
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1

PAMP

pathogen associated molecular agent - foreign molecular structures

2

DAMP

Damage associated molecular patterns

3

PRR

Pattern recognition receptors

4

TLR - and what it does

Toll like receptor have PRR - recognize PAMP and signals innate immune response - signal cascade --> expression of factors that cause/increase inflammation --> release cytokines/chemokines

5

Common foreign patterns recognized by TLR

lipopeptides, zymosan, glycolipids, dsRNA (viral), endotoxins = lipoplysaccharides, flaggellin, ssRNA (viral), unmethylated CpG, asthma

6

Final transcription factor most commonly activated in inflammation

NFkB

7

Cytokine

small protein released by cell - chemokines, interferons, interleukins, lymphokines, tumour necrosis factor

8

Chemokine

induce chemotaxis

9

Function of Innate Immune response

Detect, Inactivation, destruction, removal of intruders

10

Cell that bridge innate and adaptive

Dendritic Cell

11

DC function

Dendritic Cell s in periphery -> activated via cytokines/chemokines -> travel to lymphatics to nearest lymph node -> antigen presenting cell to lymphocytes

12

Compare speed: innate/adaptive

Innate faster - less powerful

13

Adaptive immune response uses

antigens/antibody

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T cell matures in _____

thymus

15

CTL cell is CD_?

8

16

Th cells has CD_?

4

17

5 classes of immunoglobin - antibodies

Ig: G, A, M , D, E

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Function of antibody

Bind to antigen - neutralize toxin, prevents microorganism from binding to its target cell

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Type 1 immunopathology

Immediate hypersensitivity - too much IgE - allergies, astham, anaphylactic shock --> mast cells degranulate/release histamine

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Type II immunopathology

Autoimmune due to antibodies - react against self - foreign antigen happens to look like self moelcule --> cross reaction

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Type III immunopathology

Antibody against a soluble antigen

22

Systemic lupus erythematosus

makes antibody to own DNA

23

Th1

pro-inflammatory - recruits macrophage

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Th17

More powerful than Th1, resist very though infection

25

Th2

stimulate macrophage to become alternatively activated - walling off pathogen, promote healing. Typically after Th1 is done. Important in parasite

26

Tfh

migrate from T cell in lymph to B cell follicles - activated B cell to switch classes

27

Treg

make lymphokines - suppress activation/function of sibling T helper cells - keep immune response in cehck