A&P immune system Flashcards
(24 cards)
Define erythorcytes
RBC 5x10^6/ul
Define Platelets
Fragments from megakaryocytes - 150-400 thousand/uL
Leukocytes definie
nucleated cells of blood, WBC - in buff coat
Mononuclear cells
Luekocytes who nucleus has smooth outline - monocyte + lymphocytes
Polymorphonuclear cells
Nucleus is lobulated - aka granulocytes - prominent cytoplasmic granules - Eosinophils, basophils (mast cells) and neutrophils
WBC count
4,500-10,500/uL
Neutrophil %
40-60%
Eosinophils
1-4%
Basophils
0.5-1%
Monocytes
2-8%
Lymphocytes
20-40%
Central lymphoid organs
Bone marrow, Thymus
Peripheral lymphoid organs
Lymph nodes, spleen, peyer’s patches, mesenteric lymph nodes of gut, tonsils, adenoids
Lymphocyte in blood –> ____ _____ ____ –> peripheral lymphoid tissue (lymph node) –> Lymph drains from node to node –> _____ _____ –> venous blood
post capillary venules
Thoracic duct
Antigen is defined as ____?
a substance that can be reocognized by immune system
Immunogen
an antigen that forms immune response
Tolergen
an antigen that has no immune response - prevents immune response to sequent adminstrated immunogen with same antigenic determinents
Epitope
part of antigen that fits into receptor (antigen determinant region)
Lymphocyte activation steps
Antigen fits into receptor –> several more receptors bind
Receptor binds –> cell activated when multiple receptor simultaneously bind antigen + cell surface molec
Proliferation –> divide
Differentation
T lymphocyte - T lymphoblast
B lymphocyte - B lymphoblast - plasma cell
Humoral immunity
antibody mediated
Cell mediated immuity
DC cell - no need for antibody - has receptor for “non-self”
Payer’s patch
lymph node near entrance in small intestins
DC arrive at lymph in ___
Afferent lymph - gather at interface between cortex (B cell/ and paracrotx (T)
Order from high to low concentration of WBC normally
N>L>M>E>B
