sleep

Question 1

T or F 
as eveing goes ...
melatonin decreases 
core body temp increases 
if you wnat full 8 hrs of sleep, sleep is initiated 6 hrs after temp nadir

Answer 1

melatonin decreases - F
core body temp increases -F
if you wnat full 8 hrs of sleep, sleep is initiated 6 hrs after temp nadir- before

sleep is created by two oscillaratory process ( accumulation and dissipation of sleep debt) - homeostasis and circadian clock (arousal) .

Question 2

Effects of the ff on sleep
depression/ narcolepsy
antidepressants- SSRI and heterocyclic antdepressants

Answer 2

depression/ narcolepsy - REM sleep is sooner, period bet NRE< and REM is shorthened

antidepressants- SSRI and heterocyclic antdepressants - supresses REM/ decrease the amount of time in REM

Question 3

treatmen t of choice for OSA

Answer 3

nasal CPAP

antdepressants - supresses REM/ decrease the amount of time in REM, * apneic episodes

Question 4

when sleep is freq interrupted, REM is not reached

Answer 4

Rebound increase
- inc in # REM sleep
inc REM duration/ amount
dec in REM latency

inc NE and dec in thyroxine

Question 5

5 anatomical structures in NREM

Answer 5

forebrain 
tahlamus
hypotrhalamus 
dorsal raphe nucleus 
medulla

Question 6

causes and treatemt of restless leg syndrome

Answer 6

PReggy
anemic, Vit b12 defi anemia
renal dse

txt: anemia
Ldopa/carbi
bromocriptine
pergolide

mod-severe- ropinirole

Question 7

diff catalepsy from cataplexy

Answer 7

Catalepsy- maintaining a certain position in which it is placed.

Cataplexy- paralysis of the antigravity muscles in the awake state. attack begins dueing expression of emotion.

sleep paralysis - temporary dysfunction of the RAS

Question 8

expected sleep changes
sedative/ hypnotics
stimulants/ cocaine

Answer 8

sedative/ hypnotics - reduces REM, dec in slow wave, inc in Beta and sleep spindles

stimulants/ cocaine - inc in sleep debt, upon withdrawal : Profound hypersomnia

Question 9

syndrome with hypersomnolence among males

Answer 9

Kleine Levin synd injury to hypothalamus rome- pwede rin sa females
18-20hrs
voracious eating hyoersexuality
disinhibition
can happen few days - several weks , once top 10x/yr

Question 10

conditioned arousal with the thought of sleeping

Answer 10

Psychopathological insomnia

Idiopathic insomnia- lifelong inability to obtain adequate sleep

paradoxical insomnia - px complains of difficulty sleeping but no objective evidence of sleep disruption