Smell and olfactory pathway

Question 1

Anosmia … means loss of smell is the ______ of disease of the olfactory nerves

Answer 1

Anosmia … means loss of smell is the symptom of disease of the olfactory nerves

Question 2

What other sense is affected with anosmia?

Answer 2

taste

Question 3

Olfactory epithelium contains ____ main cell types

Answer 3

3

Question 4

Olfactory receptor cells

• site of olfactory ______
• _____ neurons, with axons that penetrate the CNS
• humans have 6-10 million at any one time
• continually grow, die and regenerate over_____wk cycle

Answer 4

Olfactory receptor cells

• site of olfactory transduction
• bipolar neurons, with axons that penetrate the CNS
• humans have 6-10 million at any one time
• continually grow, die and regenerate over 4-6 wk cycle

Question 5

supporting cells

• similar to _____
• produce ____ (among other things)

Answer 5

supporting cells

• similar to glia
• produce mucous (among other things)

Question 6

basal cells

source of new ______ cells

Answer 6

basal cells

source of new receptor cells

Question 7

Label the following image

Answer 7

Question 8

Olfactory Receptors

• Encoded for by a large _____ family (at least ~1000 members)
• G protein-coupled receptors (GPCRs): 7 transmembrane domains – related to visual _____
• ____ allows for identification of a huge variety of different chemical structures

Answer 8

Olfactory Receptors

• Encoded for by a large multigene family (at least ~1000 members)
• G protein-coupled receptors (GPCRs): 7 transmembrane domains – related to visual opsins
• Diversity allows for identification of a huge variety of different chemical structures