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1
Q

Understand the formula P=G+E

A
  1. P=phenotype G=Genotype E=environment environmental effects are non-genetic factors that affect performance (phenotype)
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2
Q

Understand GxE interactions

A

Genotype x Environment The “relative” performance of different genotypes “depends” upon the environment Different Breeds/ Strains within a species may be genetically adapted to specific environments Not all interactions are genetically-adapted, they can be environmentally adpated

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3
Q

Selection

A

The process that determines which individuals become parents, how many offspring they produce, and how long they remain in the breeding population.

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4
Q

Mating

A

The process that determines which selected males are bred to which selected females; playing cupid

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5
Q

What is performance testing

A

Systematic measurement of performance (phenotype) in a population

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6
Q

How is performance testing used?

A

Varies among species and breeders in a species, usually Seedstock producers participate

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7
Q

What are some commonly measure traits for performance testing?

A

Beef cattle: pregnancy, feed conversion, yearling weight Dairy cattle: days dry, milk yield, fat and protein in milk Horses: wither height, time to move, winnings Swine: days to 230lbs., litter size, feed conversion, loin eye area Poultry: hatchability, breast weight, #of eggs, shank length Sheep: birth weight, greece fleece weight, clean fleece weight

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8
Q

Pedigree data

A

Info on the genotype or performance of ancestors and/or collateral relatives of an individual. Used to select a sire, dam and genetic predictions

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9
Q

Progeny data

A

info on the genotype or performance of descendants of an individual. Used to predict breeding value

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10
Q

What is the difference between selection of simply-inherited and polygenic traits?

A

Polygenic traits are affected by many genes w/no known single gene having an overriding influence. Simply-inherited traits use one or just a few genes.

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11
Q

Law of Segregation

A

During gamete formation, the alleles for each gene segregate from each other so that each gamete carries only one allele for each gene

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12
Q

Law of independent Assortment

A

Genes for different traits can segregate independently during the formation of gametes

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13
Q

Law of Dominance

A

Some alleles are dominant while others are recessive; an organism w/at least one dominant allele will display the effect of the dominant allele

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14
Q

Punnett Square

A

A device for determining genotypes of possible zygotes obtainable from a mating

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15
Q

Complete Dominance

A

The expression of the heterozygote is identical to the expression of the homozygous dominant genotype

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16
Q

Partial Dominance

A

The expression of the heterozygote is intermediate to the expressions of the homozygous genotypes but more resemebles the expression of the homozygous dominant genotpe

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17
Q

Codominance (No Dominance)

A

The expression of the heterozygote is exactly midway between the expression of the homozygous genotypes

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18
Q

Over Dominance

A

The expression of the heterozygote is outside the range defined by the expressions of the homozygous genotypes but mostly closely resembles the expression of the homozyous dominant genotype

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19
Q

Epistasis

A

An interaction among genes at different loci such that the expression of genes at one locus depends on the alleles present at one or more loci. Masking is when one locus masks the other. Modifying is breeding for a specific trait

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20
Q

Compare and contrast sex chromosomes in mammals and birds

A

Mammals: male determines sex, uses XY and XX Birds: Female determines sec, uses ZW and ZZ

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21
Q

Sex-linked inheritance

A

the pattern of inheritance for genes located on sec chromosomes (X or Y) ex. calico cats and color blindness

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22
Q

Sex-limited inheritance

A

The phenotypic expression is limited to one sex (gender) however, other gender still has alleles for trait ex. antlers and facial hair

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23
Q

Sex-Influence inheritance

A

Modes of gene expression differ between males and females; allele may be dominant in one gender, but recessive in the other gender. ex. horns in sheep and scurs in cattle

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24
Q

What is gene or allelic frequency?

A

Frequency of a particular allele p= frequency of dominant allele q= frequency of recessive allele

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25
What is genotypic frequency?
Frequency of a particular one-locus genotype P=Dominant Homo H=Hetero Q=Recessive Homo
26
What are F1 and F2 generations?
F1: first generation of crosses between two unrelated populations F2: Subsequent generation of crosses produced by mating F1 individuals among themselves
27
What are the effects of Outbreeding and Inbreeding on genotypic and gene frequencies?
Outbreeding: mating of same species but different breed Inbreeding: mating of relatives
28
What are the effects of outbreeding and inbreeding on heterozygosity and homozygosity?
Outbreeding: increases the frequency of heterozygosity and decreases the frequency of homozygosity Inbreeding: increases the frequency of homozgyosity and decreases the frequency of heterozygosity
29
What is the Hardy-Weinberg Equilibrium?
A state of constant gene and genotypic frequencies occurring in a population in the absence of forces that change those frequencies.
30
How does H-W E relate to genotyipc and allelic/gene frequencies?
p^2+2pg+q^2=1 P=p^2 H=2pg Q=q^2
31
What are primary and secondary differences between simply-inherited and polygenic traits?
Simply-inherited is a trait affected by one or only a few genes (loci), phenotyes tend to be qualitative or categorical, sometimes categories are rated w/a score, typically affected very little by the environment. Polygenic is a trait affected by many genes, phenotypes tend to be quantitative, typically affected by the environment.
32
How is selection of polygenic traits different than simply inherited traits?
Instead of identifying genotypes a breeder tries to identify breeding values of individuals for traits of importance and to select those w/the best breeding value
33
What is quantitative genetics?
The branch of genetics concerned with influences on measurement of, relationships among, genetic prediction for, and rate of change in traits that are or can be treated as quantitative.
34
Utilization of population mean µ in the Genetic Model for Quantitative Traits ( P=µ+G+E)
In animal breeding, genotypic values and environmental factors are relative to the population being considered.
35
G=BV+GCV (Breeding value+ Genetic Combination Value)
The part of an individual's genotypic value that is due to the effects of gene combinations and cannot therefore be transmitted from parent to offspring
36
E=Ep+ET (Permanent Environementa Effects + Temporary Environmental Effects)
Permanent Effects (calfhod nutrition, Horse training, injuruy), Temporary Effects (forage quality, track conditions, season temps)
37
Heritability
What extent differences we observe in animal performace is due to inheritance; easure of the strength of the relationship between performance and the breeding values for a trait in a population
38
Repeatability
A measure of the strength of the relationship between single performance records and producing abilities for a trait in a population
39
What is the importance of contemporary groups?
Correctly formed: increase Heritability and Repeatability Incorrectly formed: decrease Heritability and Repeatability; distort Performance records and genetic prediction for individual animals; usually occur when some animals get preferential treatment
40
What are the factors taht affect genetic change?
Directly Proportional: accuracy of selection; selection intensity; genetic variation Inversely Proportional: Generation interval
41
Accuracy of Selection
The measure of the strength of the relationship between true breeding values and their predictions for a trait under selection
42
Selection of Intensity
Measure of how "choosy" breeders are in deciding which individuals are selected
43
Genetic Variation
The variability of breeding values within a population for a trait under selection
44
Generation interval
The amount of time required to replace one generation w/the next
45
What are the two methods used for Genetic Prediction
Selection index: used to compare animas using data from genetially SIMILAR groups BLUP (Best Linear Unbiased Prediction): Used to compare anials using Data from genetically DIVERSE groups
46
What are Sire Summaries?
Most visible product of large scale genetic evaluation, Contain three types of data: animal indentification; misc. info including simply-inherited traits; and prediction and accuracy measures
47
What are nucleus breeding schemes?
A cooperative breeding program in which elite animals are concentrated in a nucleus herd of flock and superior germ plasm is then distributed among cooperating herds or flocks
48
What are the methods of multiple-trait selection?
Tandem Selection Independent Culling Levels Economic Selection Index
49
Tandem Selection
Slection first for one trait, then another Serial selection: breeder selects for a trait until selection target is met Selection target: a level of breeding value considered optimal in an absolute or practical sense Doesnt work well when traits are unfavorably correlated
50
Independent Culling Levels
Min. standards for traits undergoing multiple-trait selection Animals failing to meet any one standard are rejected regardless of merit in other traits Animal breeders tend to use an intuitive/experiential approach rather than mathematical precise approach
51
Economic Selection Index
An index or combination of weighting factors and genetic info phenotypic data or genetic prediction Economic Selection indexes are used in multiple-trait selection to predict aggregate breeding value
52
Understand backcrossing/introgression
A mating system used to incorporate an allele or alleles existing on one population into another population. The mating of a hybrid to a purebred of a parent breed or line
53
Understand Topcrossing/ Grading Up
Mating system designed to create a purebred population by mating successive generations of non-purebred females to purebred sires. A mating syste designed to convert a population from one breed into another by mating successive generations of females descended from the first breed to sires to the second breed.
54
55
What are the mating systems based on performance?
Random mating; positive assortative mating; negative assortative mating \*\*look at chart for comparisons\*\*
56
Corrective Matings
A mating system designed to correct progeny faults from one or both parents
57
Comlpementarity
An improvement in the overall performances of offspring resulting from the mating of individuals
58
When would a producer used Positive Assortative
To breed top end cows to top bulls
59
When would a producer use negative assortative
Use corrective matings to correct problems in certain cows
60
When would a producer used random matings
Use young bulls randomly to breed heifers and middle cows
61
Understand When and why (why not) linebreeding/linecrossing and crossbreeding is used in performance mating?
Increase Heterozygosity; decrease homozygosity; masking of the expression of deleterious recessiv alleles w/major effects; increases Hybrid Vigor (heterosis); Hybrid Vigor: ertility and survivability traits, Conception rate, litter size, weaning rate; Breed complementarity; get an intermediate phenotype, maternal x paternal (terminal) crosses
62
Whst are maternal breeds and exs?
Traits from the dam, maternal instinct, angus, herefored
63
What are paternal breeds and exs?
Traits from the sire, market traits Charolais, Limousin
64
What are terminal crosses?
Combinwes a maternal rotation for producing females w/terminal sires for producing market offspring
65
What is inbreeding?
The mating of relatives, the mating of relatives more closely related than avg.
66
What are the effects of inbreeding in mating systems?
Increase homozygosity Greater prepotency Expression of deleterious recessive aleles Decreases in performance-inbreeding depression
67
What is inbreeding depression and how is it related to Hybrid Vigor?
A decrease in the performance of inbred offspring, mostly noticeable in traits like fertility and survivability
68
What are the reasons to inbreed?
To increase uiformity and to create an opportunity for hybrid vigor
69
What is purebreeding/straightbreeding?
The mating of purebreds of the samebreed, crossing these breeds result in substantial levels of hyrid vigor
70
What is outbreeding?
The opposite of inbreeding, the mating of unrelated individuals
71
What are the two types of outbreeding?
Crossbreeding and linecrossing
72
What are the effects of outbreeding in mating systems?
Increase heterozygosity Decrease homozygosity Masking expression deleterious recessive alleles w/major effects Increases hyrid vigor
73
When and how are inbreeding and outbreeding used in the industry structure?
Crossbreeding is commonly used by commercial producers Seedstock producers commonly use linecrossing to enhance purebreeding
74
When is Hyrid Vigor at a max.?
H.V. is maximized in the F1 generation or the first cross of unrelated populations
75
How is H.V. retained and/or diminished?
Hybrid vigor remaining in later generations of hybrids i.e. generations subsequent to the first cross RHV=F2HV/F1HV
76
What is crossbreeding?
The mating of sire of one breed to dams of another breed. Crossbreeding systems are mating systems are mating system that uses crossbreeding to maintain a desirable level of hybrid vigor and/or breed complementarity.
77
78
How are crossbreeding systems evaluated?
Find the system whose upside is expecially beneficial for the situation and whose downside is relatively less harmful
79
Merit of component Breeds
Breeds in system must be well chosen and must bring favorable attributes to the traits, sometimes can be improved w/crossbreeding
80
Hybrid Vigor/Heterosis
Probably the most important reason for crossbreeding maximal hybrid vigor is only found in F1 generation
81
Breed Complementarity
Production of more desirable offspring by crossing breeds that are genetically different from each other but have complementary attributes Sire x Dam- the classic form Hybrid Seedstock- crossing genetically diverse breeds
82
Consistency of Performance
An ideal crossbreeding system should produce a consistent product Crossbreeding systes vary in their ability to provide consistency
83
Replacement Considerations
Crossbreeding systems can be designed allowing commercial breeders to produce replacement animals from their own hybrid population
84
Simplicity
Crossbreeding systems should be relativey simple
85
Accuracy of Genetic Prediction
The higher the accuracy of genetic prediction, the lower the selection risk, and the more predictable the offspring
86
Rotational Systems
Spatial Rotations: Purebred Sires-all sires used simultaneously and Crossbred Sires- only difference, breed composition Rotations in Time: sire breeds are not used simutaneously, but are introduced in sequence
87
Terminal Sire Systems
Maternal-breed females are mated to paternal-breed males to efficiently produce progeny that are especially desirable from a market standpoing
88
Static Terminal System
replacement females are either purchased or produced from separate purebred populations within the system
89
Rotational/ Terminal System:
90
Pure Composite System
a mating system limited to matings within a single composite breed
91
Composite/ Terminal System
a crossbreeding system combining maternal composite breed for producing replacement females w/terminal sires for producing market offspring
92
Artifical Insemination
Advantages: genetic improvement, control of STDs, accurate breeding records, exonomic, safety Disadvantages: need trained technician, need to corral and restrain females, costs
93
Embryo Transfer
Advantages: can increase offspring from genetically superior females, obtain offspring from aniamls that cant carry pregnancies to term Disadvantages: costly, need trained technicians, need to corral and restrain females
94
In Vitro Fertilization
Advantages: utilization of prepubertal and slaughterhouse animals, increase number of pregnancies possible, decrease generatio interval Disadvantages: expensive, trained technicians needed
95
Sex Control:
increase speed of genetic changes, improve accuracy of selection and selection intensity, decrease generation interval
96
Cloning
Advantages: immediate improvement in avg. genetic merit of a herd or flock, causes uniformity, large increase in accuracy of selection and intensity of selection Disadvantages: no genetic variation for future improvemennt, environmental effects could be detrimental, excessive inbreeding possible, costly
97
Same-sex mating
rate of genetic change would be increased by increasing accuracy of seleciton and selection intensity
98
How are hormones used in some of the Reproductive Biotechnologies?
Used to sync females so that they can be artificailly inseminated at the same time used in embryonic transfer to cause females to over-ovulate
99
What is conversation genetics?
The branch of genetics dedicated to preservation of germ plasm, maintains genetic diversity
100
Molecular Technologies
DNA fingerprinting, Marker Assisted Selection, Gene Transfer/ Transgenics/ GMOs
101
DNA fingerprinting
A laboratory method for graphically characterizing an individual's DNA, creating a unique genetic "fingerprint" Identificaiton of parentage, measurement of "purebred" status in grading up/topcrossing through backcrossing, prediction of H.V.
102
Marker Assisted Selection
Selection of specific alleles using genetic markers
103
Gene Transfer/Transgenics/ GMOs
Transplantatio of specific genes from one individual to another using laboratory techniques Improved production traits, improve animal health
104
Recommendations for commonsense animal breeding
Be knowledgable: understand the basic concepts of genetics, selection, mating, and biotechnology Use good info: good decisions are based on good info take time to think: whats best for the animal? Be consistent; set goals and stick to them Keep it simple: complex breeding progrmas are difficult to maintain Be patient: change doesnt happen overnight; randomness will sometimes lead to setbacks

Ag genetics (22 decks)

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