Flashcards in sympathomimetics Deck (16):
epinephrine: most affected receptors, applications
beta effects more important than alpha effects at low doses; alpha effects predominate at high doses. used for anaphylaxis, open angle glaucoma, asthma, and hypotension.
norepinephrine: affected receptors, applications
alpha 1> alpha2 > beta1. used for hypotension, but decreases renal perfusion
isoproterenol affected receptors, applications
beta receptor agonist. used to evaluate tachyarrhythmias, but can worsen ischemia
dopamine affected receptors, applications
D1=D2 > beta >alpha. used for unstable bradycardia, heart failure, shock. inotropic and chronotropic effects predominate at high doses.
dobutamine affected receptors, applications
B1 > B2, alpha. used for heart failure and cardiac stress tests
phenylephrine affected receptors, applications
alpha 1 > aplpha 2. used for hypotension, ocular procedures (mydriatic), rhinitis
albuterol affected receptors, applications
(salmeterol and terbutaline are like this too). Beta2 > beta 1. used for acute asthma.
terbutaline affected receptors, applications
like albuterol, B2> B1. used to prevent premature uterine contractions.
salmeterol affected receptors, applications
used for long term asthma/COPD control
amphetamine: mechanism and clinical application
indirect general agonist and reuptake inhibitor. it also releases stored catecholamines. good for narcolepsy, obestiy, and ADD
ephedrine affected receptors, applications
indirect general agonist. releases stored catecholamines. used for nasal deconsgestion and treatment of urinary incontinence and hypotension.
indirect general agonist and reuptake inhibitor. it causes vasoconstriction and local anesthesia. NEVER give a beta blocker to someone with cocaine intoxication because of unopposed alpha-1 activation and extreme hypertension.
compare and contrast norepinephrine and isoproterenol: effects on BP, and HR, with explanation
NE is an agonist at alpha 1 > alpha 2 > beta 1 receptors. isoproterenol works on beta receptors. therefore, NE will cause increased blood pressure d/t alpha-mediated vasoconstriction. high pressures can cause bradycardia. Isoproterenol, on the other hand, causes beta-2 mediated vasodilation: decr. mean arterial pressure and incr. HR through beta 1 and reflex actity
an alpha-2 agonist that acts as a sympatholytic. used for hypertensive urgency. doesn't decr. renal blood flow. also for ADHD, severe pain (off-label uses like ethanol and opioid withdrawal)
CNS depression, bradycardia, hypotension, resp. depression, small pupil size