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Final Multisystems Microbiology > Systemic Spirochetes > Flashcards

Flashcards in Systemic Spirochetes Deck (15)
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1

Discuss spirochetes in general

Spiral shaped organisms that exhibit corkscrew motility, don’t gram stain.

2

Discuss the three stages of syphillis in adults

1*= genital chancre (nonpainful)
2*= condyloma latum (warts), rash hands/feet, mucous patches in mouth
3*= neuro damage, damage to vasa vasorum (blood supply to aorta)--> damage to aorta→ ("tree bark"), Argyll Robertson pupils (can accommodate, can’t react to light), gumma formation

3

Discuss congenital symptoms of syphilis

Baby= saber shins, saddle nose, hutchinson's teeth, mulberry molars, deafness, hydrops fetalis, death,

4

How do we diagnose Syphillis?

Dx: Dark field microscopy (direct visualization), lab blood test

- VDRL /RPR screening: non-treponium
- FTA-AB screening: treponium

Many false (+)

Silver stain needed to visualize, but note, can not be grown in culture, must be propagated in experimental animals

5

How do we teat syphillis?

Tx: PCN (may induce fevers/chills/HA)

6

Source for Leptosporosis

source: animal urine, contaminated water

7

How does Leptosporosis present?

Sx: Acute febrile illness with conjunctival suffusion that may progress to jaundice and renal failure (Weil’s disease) or meningitis.

8

Who is at risk for Leptosporosis?

At risk: Soldiers wading in water/streams during field exercises

9

Where do we find Lyme Disease?

Source: primarily in the NE, from ticks (ixodes scapularis type). Tick=vector. Most common arthropod-borne infection in the U.S. Nymph stage of the tick in the months of May - July is the most contagious.

10

Discuss the life cycle of Lyme Disease

Life cycle: White footed mouse= reservoir for larvae; white tailed deer = obligatory host for adult form (deer immune)

11

How do we diagnose Lyme Disease?

Dx: Wright stain, Giemsa stain, Synovial fluid if they have arthritis.

12

Discuss the stages of lyme disease and what symptoms present at each

Stage 1: bull’s eye rash (w/in a month of bite), flu-like sx (fever+chils) (Local spread of infection causing erythema migrans)

Stage 2: bilateral bell’s palsy, heart block caused by myocarditis, erythema migrans in other locations (from dissemination of bacteria, weeks to months later).

Stage 3: encephalopathy (memory problems, meningitis or other CNS sx), migratory polyarthritis starting w/ large joints (like knee), acrodermatitis all due to persistent long term survival

13

What is STARI?

STARI - Southern Tick-
Associated Rash Illness - Rash similar to that of lyme disease in people residing in southeastern and south-central states, associated with bite from a tick with a lone star on its back (Amblyomma americanum.

14

What happens with relapsing fever in Borrelia?

Sx: Relapsing fever - Caused by Borrelia, characterized by recurrent episodes of fever separated by asymptomatic intervals. Louse born = transmitted from person to person with no animal reservoir = epidemic form = Borrelia recurrentis. Tick borne = transmitted from animals to humans = endemic form = Borrelia hermsii.

15

How do we treat Lyme Disease?

Tx: Doxycycline (stage 1), Ceftriaxone (stage 3)