t cells

Question 1

T cells only recognize

Answer 1

peptides

Question 2

T cells only recognize antigen when

Answer 2

“presented”

Question 3

T cells only react to antigen when placed on

Answer 3

“self” MHC

Question 4

CD4 T cell role

Answer 4

produce cytokines, activate other cells, direct immune response

Question 5

CD8 T cell role

Answer 5

kill virus infected cells

Question 6

CD4 T cells are activated by

Answer 6

antigen presenting cells, MHC class II

Question 7

B7 protein on APC binds __ on CD4 T cells

Answer 7

CD28

Question 8

CD4 T cell activation stimulates

Answer 8

B cells, CD8 T cells, macrophages

Question 9

Th1 cells activate

Answer 9

CD8 cells & macrophages

Question 10

Th1 cells promote

Answer 10

specific IgG subclasses

Question 11

__ from macrophages drive Th1 production

Answer 11

IL-12

Question 12

Th2 cells activate

Answer 12

B cells to produce antibodies

Question 13

Th1 cytokines

Answer 13

IL-2, INF gamma

Question 14

IL-2 role

Answer 14

T cell growth factor

Question 15

INF gamma role

Answer 15

activates Th1 & macrophages

Question 16

Th2 cytokines

Answer 16

IL-4, IL-5, IL-10

Question 17

IL-4 role

Answer 17

promotes IgE production

Question 18

IL-5 role

Answer 18

promotes IgA production, activates eosinophils

Question 19

IL-10 role

Answer 19

inhibits Th1, anti inflammatory

Question 20

Th1 is import for

Answer 20

many intracellular infections

Question 21

Crohn’s disease

Answer 21

TH1 mediated

Question 22

ulcerative colitis

Answer 22

Th2 mediated

Question 23

IL-12 receptor deficiency

Answer 23

cannot trigger differentiation of Th1
leads to decreased macrophages

Question 24

INF gamma deficiency

Answer 24

INF gamma not effective, need cont anti microbial therapy

Question 25

MCH class 1 binds

Answer 25

TCR and CD8

Question 26

CD8 function

Answer 26

insert performs & granzymes & produce fas ligand

Question 27

regulatory T cell role

Answer 27

suppress CD4 & CD8

Question 28

reg T cell produce what cytokines

Answer 28

IL-10, TNF beta

Question 29

classical marker of t reg cells

Answer 29

CD25

Question 30

Th17 is important for

Answer 30

mucosal immunity

Question 31

super antigens cause

Answer 31

toxic shock syndrome

Question 32

for a t cell to survive it must

Answer 32

bind to self MHC and not bind in presence of self antigens

Question 33

where does positive selection take place

Answer 33

thymus cortex

Question 34

where does negative selection take place

Answer 34

thymus medulla

Question 35

genes responsible for expression of self antigens

Answer 35

AIRE genes