Targeted drugs Flashcards
(28 cards)
What 4 drugs EGFR?
- Gefitinib (Iressa)
- Erlotinib (Tarceva)
- Cetuximab (Erbitux)
- Panitumumab (Vectibix)
What 2 drugs target ERBB2 (HER2)?
- Trastuzumab (Herceptin)
- Lapatinib (Tykerb)
What 3 drugs target BCR-ABL?
- Imatinib (Gleevec)
- Dasatinib (Sprycel)
- Nilotinib (Tasigna)
What drug targets BRAF?
- Vemurafenib (Zelboraf)
What drug targets CTLA-4?
- Ipilimumab (Yervoy)
What does masitinib (Kinavet, masivet) target?
KIT
PDGFRa/b
Lyn
Fyn
FGFR3
What does Palladia target?
KIT (CD117)
VEGFR2
PDGFRb
Flt-3
CSFR1
RAF
What does sunitinib (Sutent) target?
VEGFR1/2/3
PDGFRa/b
RET
CSFR1
Flt-3
What does oclacitinib (Apoquel) target?
JAK 1 > JAK3
Name 3 mTOR inhibitors.
- Rapamycin (Rapamune)
- Temsirolimus (Torisel)
- Everolimus (Zortress)
Name a JAK2 inhibitor that improves QOL (not curative).
Ruxolitinib (Jakafi)
Name a RANKL antagonist?
osteoprotegerin
What are the targets for sorafenib (Nexavar)?
VEGFR2-3
C-RAF
B-RAF
VEGF-C
FLT3
FGFR1
KIT
p38
PDGFR
RET
Name two PD-1 inhibitors.
- Pembrolizumab (Keytruda)
- Nivolumab (Opdivo)
Name a PD-L1 inhibitor.
Atezolizumab (Tecentriuq)
Name a monoclonal antibody that targets CD52 in CLL.
Alemtuzumab (Lemtrada)
What mAb targets VEGF?
Bevacizumab (Avastin)
What mAb targets CD33 in AML? What toxin does it deliver?
- Gemtuzumab (Milotarg)
- ozogamicin
What mAB’s target CD20? Include toxins for modified ab’s.
- Ibritumomab (Zevalin), toxin: yttrium-90
- Ofatumumab (Arzerra)
- Rituximab (Rituxan)
- Tositumomab (Bexxar), toxin: I-131
Name a bispecific antibody that mediates regression of NH B cell LSA and is specific for CD19 and CD3?
Blinatumomab (Blincyto)
Name a small molecule inhibitor that targets EML4-ALK translocation seen in a subset of patients with NSCLC.
Crizotinib (Xalkori)
What small molecule inhibitor can be used to treat resistance from EGFR therapy for NSCLC?
Osimertinib (Tagrisso)
Name a BTK inhibitor.
Ibrutinib (Imbruvica)
Name two small molecule inhibitors of PI3K-gamma-delta.
tenalisib and duvelisib
