the nervous system (part 1-electrical and action potential) Flashcards

(49 cards)

1
Q

this is the primary cell type found in the central nervous system and it exhibits electrical properties

A

neuron

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2
Q

most neurons have 6 structures:

A

cell body w/ nuclues in it, dendrites, axon, myelin, synaptic terminals

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3
Q

this part of the neuron houses the nucleus and other membrane bound organelles

A

cell body

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4
Q

the part of the neuron that receives signals

A

dendrites

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5
Q

long projection away from the body of a neuron that relays electrical signals

A

axon

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6
Q

part of the neuron that is a lipid-rich sheath that insulates axon to increase action potential speed

A

myelin

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7
Q

the part of the neuron where neurotransmitters are released

A

synaptic terminals

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8
Q

what is the name of the space between neurons

A

synapse

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9
Q

the signature cell type (neuron) of the hippocampus with a long axon and lots of dendrites

A

pyramidal cells

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10
Q

a large cell (neuron) found almost exclusively in the cerbellum, they are very dense with dendrites, mostly just transmit GABA, and help serve as a cerebellum control center

A

Purkinje cells

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11
Q

the most abundent cell (neuron) in the nercous system and one of the smallest; do not have many dendrites and mostly transmit glutamate

A

granule cell

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12
Q

this neuron is almost exclusively found in the spinal cord, is very small, mostly inhibits and has very short axon

A

interneuron

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13
Q

the classic neuron with all the perfect structures we study is also called a ________ neuron

A

multipolar

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14
Q

these cells provide critical support for neurons in the CNS and nerve cells in the PNS

A

neuroglia or glial cells

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15
Q

what 2 neuroglia cells are in the peripheral nervous system

A

satellite cells and schwann cells

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16
Q

what 4 neuroglia cells are in the CNS?

A

microglia, oligodendrocytes, ependymal cells and astrocytes

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17
Q

what glial cell does this describe?:

regulates blood flow, PH and osmolarity
filters out toxins to help support blood brain barrier
assists in neurotransmitter reuptake (typically glutamate)

A

astrocytes

hint : STAR (astro) cleaners and regulaters

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18
Q

what glial cell does this describe?:

function as immune cells for CNS
-start immune response when pathogens are detected, recruit non-neural immune cells to help
mediate level of inflammation in the CNS
act as phagocytes (immune cell that “eats” pathogens)

A

microglia

hint: Small (micro) but mighty fighters

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19
Q

these glial cells are ciliated (meaning they have hair-like cilia surrounding them), circulate and filter cerebrospinal fluid and main its homeostasis

A

ependymal cells

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20
Q

These specialized glial cells in the CNS are responsible for myelination, they extend a foot process from their cell body to wrap around the axon

A

oligodendrocytes

hint: funky name, funky foot, foot process, myelination

21
Q

this peripheral glial cell is also responsible for myelination, entire cell wraps around axon to myelinate it thought not just an extension

A

schwann cells -PNS

22
Q

these PNS glial cells are very similar to astrocytes; they regulate extracellular matrix surrounding the peripheral nerve cells, possibly aid in neurotransmitter reuptake and provide physical cushion for nerve cells in the PNS

A

satellite cells

hint: satellites are far (periphery) and surround and help protect us (surround nerve cells and given cushion)

23
Q

in the equivalent circuit model this refers to the charge difference across the cell membrane, measured in millivolts mV

A

voltage or potential -V

24
Q

in the equivalent circuit model this is a measure of the flow of individual ions measured in milliamps (mA)

25
in the equivalent cicruit model this is a measure of the impedance of current in a circuit and is a function of the neuron, cell membrane and axon as a whole, measured in milliohms (mO). there are 2 types of this
resistance -R (membrane resistance and longitudinal resistance)
26
in the equivalent cicruit model this is a measure of the cell membrane's ability to store electrical charge and id dependant upon physical propertoes of the cell membrane and axon
capacitance -C
27
membrane resistance is influenced by what aspect of a neuron?
amount of myelin present
28
how does more myelination affect an an action potential
increases speed/efficiency
29
longitudinal resistance is influenced by what aspect of a neuron?
diameter of the axon
30
how does a larger diameter effect action potential?
increase speed and efficiency
31
how do you best decrease membrane resistance and longitudinal resistance?
increase myelination and diameter of the axon
32
what law is this? I=V/R current= voltage/resistance OR V= I x R voltage = current x resistance
ohm's law
33
this is a representation of how long it takes a neuron to respond to a stimulus and is the product of a neuron's membrane resistance and membrane capacitance
time constant (t)
34
what is the formula to calculte time constant
τ= Rm x Cm
35
this is a representation of the distance a subthreshold potential (graded potential) will travel along a neuron before decaying. it is related to the square root of a neuron's membrane resistance divided by its longitudinal resistance
space constant
36
formula for space constant
λ = square root of (Rm/Rl)
37
what does increasing Rm or Cm do to the time constant
increases time constant meaning it takes more time for a neuron to respond to a stimulus
38
what does a larger space constant indicate about a neuron's graded potential?
the potential can travel a further distance before decaying
39
the membrane potential that corresponds to the time at which a single ion is at equilibrium is known as...
equilibrium potential for that ion
40
what do you need to calculate the equilibrium potential for a given ion? and what is this equation called
intracellular and extracellular concentrations of that ion, Nernst equation
41
what is the typical threshold potential needed to fire an action potential in most neurons? (hint in mV)
-55 mV
42
when a neuron is not firing an action potential, it maintains a stable resting potential(largely bc of the sodium-potassium pump) that is typically ____ mV
-70 mV
43
the action potential must proceed in one direction: from the cell body/soma (more specifically axon hillok-junction of soma and axon) to the _______ _______
synaptic terminal
44
graded potentials are _____-distance action potentials
short
45
what are the 3 phases of an action potential? and what happens at each?
1. polarization- voltage gated Na+ channels open so sodium flows in 2. repolarization -sodium ions reach equilibrium so voltage-gated channels close and voltage-gated K+ channels open so Potassium starts to flow out 3. hyperpolarization- the membrane potential briefly dips below the resting membrane potential due to excess K+ exiting cell, sodium potassium pump helps return to RMP
46
what is the role of the sodium-potassium pump in an action potential
restore normal resting membrane potential during the hyperpolarization phase
47
what does the sodium potassium pump do specifically?
forces 3 sodium out and 2 potassium in against both their concentration gradients using ATP; antiport?
48
myelin allows for what type of conduction
saltatory conduction
49
ion channels are onyl present in the gaps between myelin segments and these gaps are known as
the nodes of ranvier