Flashcards in Thyroid Deck (12):
L-triiodothyronine- T3. Potent, short-acting T3. Used for short-term suppression of TSH.
Liothyronine sodium: safety
More difficult to monitor than T4, increased risk of cardiotoxicity
L-thyroxin (T4). Drug of choice for replacement in hypothyroidism. T4 is converted to T3 by deiodinase 1. Once daily dosing.
Levothyroid sodium: safety
SE: Angina, palpitations.
Warning: dose adjust for elderly and pregnant patients.
Rifampin increases T4 clearance, cholestyramine decreases absorption
Target: TPO (thyroidal peroxidase) prevents hormone synthesis AND peripheral conversion of T4 to T3. Used to treat thyrotoxicosis, thyroid storm.
SE: rash, joint pain, agranulocytosis
hepatotoxic (worse than MMI).
Preferred antithyroid medication in pregnant and nursing patients.
anti-thyroid drug used to treat thyrotoxicosis. Prevents hormone synthesis by blocking TPO (thyroidal peroxidase).
Less hepatotoxic than PPT. MMI is preferred in pregnancy. Longer half-life than PPT.
Can cause congenital scalp defects.
used in hyperthyroidism before thioamides were created. Combined w/ PTU and beta blocker in tx of thyroid storm.
actinform rash, swollen saliva glands, mucous membrane ulcerations.
CI in pregnancy (fetal goiter)
I-131 - use and safety
Tx of thyrotoxicosis. CI in pregnancy and children. Will eventually cause hypothyroidism.