Flashcards in Toxicology Deck (11):
What are the organs targeted by Carbon monoxide? 2
What are the effects? 3
Brain & heart (highest demand for oxygen)
Congestion, edema and hemorrhage
What is the organ most affected by NOx, ozone? How?
Forms ROS, disrupts lipid membranes, esp. alveoli
What is the effect of Sulfur dioxide?
Initially Upper airways
Then Lower airways
What are the effects of Arsenic in 5 important organs?
Where does it accumulate in short and long term?
- Cardiovasc: vasodilation, hypotension, arrhythmias, CHF
- GI tract
- Nervous system
Short term accum: major organs
Long term accum: integument due to affinity to keratin, bone and teeth
What are the 2 organs affected by Cadmium? What is its effect?
- Kidneys: affecting Vit D conversion, leads to serious bone loss (osteoporosis and osteomalacia)
- Storage in bones
- Crosses BBB, affects IQ and behavior
Acute exposure: encephalopathy, nephropathy, GI effects
Chronic exposure: repro, HTN, gout, *anemia*, CNS, neuropathy
- CNS (including prenatal exposure), sensory loss, ataxia, disequilibrium
Cyclodienes (halogenated insecticides)
- CNS stimulant by inhibiting GABA, causes convulsions and jerking
PCBs: halogenated industrial stuff
- Liver enzymes
Brominated flame retardants: PBDEs
Tons of effects in rodents, but not sure how it impacts human health...yet. Possibly carcinogenic