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Flashcards in Tumor Suppressor Genes Deck (15):
0

What is the neoplasm associated with gene APC
and its product?

Colorectal ca (associated with FAP)

1

What is the neoplasm associated with gene BRCA 1 & BRCA 2
and its product?

Breast ca
Ovarian ca
DNA repair protein

2

What is the neoplasm associated with gene CPD4/SMAD4?

Pancreatic ca

3

What is the neoplasm associated with gene DCC?

Colon cancer

4

What is the neoplasm associated with gene MEN1?

MEN type 1

5

What is the neoplasm associated with gene NF1
and its product?

Neurofibromatosis type 1
RAS GTPase activating protein (neurofibromin)

6

What is the neoplasm associated with gene NF2
and its product?

NeuroFibromatosis type 2
Merlin (schwannomin) protein

7

What is the neoplasm associated with gene p16
and its product?

Melanoma
Cyclin-dependent kinase inhibitor 2A

8

What is the neoplasm associated with gene p53
and its product?

Most human cancers
Li-Fraumeni syndrome
Transcription factor for p21, blocks G1==>S phase

9

What is the neoplasm associated with gene PTEN?

Breast ca
Prostate ca
Endometrial ca

10

What is the neoplasm associated with gene Rb
and its product?

Retinoblastoma
Osteosarcoma
Inhibit E2F, blocks G1==>S phase

11

What is the neoplasm associated with gene TSC1
and its product?

Tuberous Sclerosis
Hamartin Protein

12

What is the neoplasm associated with gene TSC2
and its product?

Tuberous Sclerosis
Tuberin protein

13

What is the neoplasm associated with gene VHL
and its product?

Von Hippel-Lindau Dx
Inhibits hypoxia inducible factor 1a

14

What is the neoplasm associated with gene WT 1&2
and its product?

Wilms Tumor (nephroblastoma)