Treponema Pallidum Flashcards
1
Q
Treponema Pallidum causes what?
A
Syphillis, Yaws, and Pinta
2
Q
What three genera of spirochetes cause human infection?
A
- Treponema
- Borrelia (lyme disease)
- Leptospira
3
Q
The morphology of Treponema Pallidum can be seen by?
A
- Dark field microscopy
- Silver impregnation method
- Staining with specific anti-trep
4
Q
VF of Treponema Pallidum?
A
- OMPs
- Hyaluronidase
5
Q
What is the role of hyaluronidase?
A
facilitates perivascular infiltration
6
Q
Spirochetes characteristics?
A
- Very few surface proteins
- Lipoprotein anchored to c-membrane
- NO LIPID A (endotoxin)
7
Q
Trep pallidum has how many stages and what stages are contagious?
A
Trep pallidum has 3 stages (Primary, Secondary, Tertiary). But, stage 1 and 2 are contagious
8
Q
what would be the consequence of a primary infection?
A
Chancre
9
Q
What would be the consequence of a secondary infection?
A
- Lymphadenopathy Rash: palms and soles
- Condylomata lata (painless) and patchy alopecia
10
Q
What would bet he consequence of a secondary infection?
A
- paralytic dementia
- aortic aneurysm
- tabes dorsalis
- gummas
