Treponema Pallidum

Question 1

Treponema Pallidum causes what?

Answer 1

Syphillis, Yaws, and Pinta

Question 2

What three genera of spirochetes cause human infection?

Answer 2

1. Treponema
2. Borrelia (lyme disease)
3. Leptospira

Question 3

The morphology of Treponema Pallidum can be seen by?

Answer 3

• Dark field microscopy
• Silver impregnation method
• Staining with specific anti-trep

Question 4

VF of Treponema Pallidum?

Answer 4

• OMPs

- Hyaluronidase

Question 5

What is the role of hyaluronidase?

Answer 5

facilitates perivascular infiltration

Question 6

Spirochetes characteristics?

Answer 6

• Very few surface proteins
• Lipoprotein anchored to c-membrane
• NO LIPID A (endotoxin)

Question 7

Trep pallidum has how many stages and what stages are contagious?

Answer 7

Trep pallidum has 3 stages (Primary, Secondary, Tertiary). But, stage 1 and 2 are contagious

Question 8

what would be the consequence of a primary infection?

Answer 8

Chancre

Question 9

What would be the consequence of a secondary infection?

Answer 9

• Lymphadenopathy Rash: palms and soles

- Condylomata lata (painless) and patchy alopecia

Question 10

What would bet he consequence of a secondary infection?

Answer 10

• paralytic dementia
• aortic aneurysm
• tabes dorsalis
• gummas