ulcerative colitis Flashcards

1
Q

what is it

A

chronic inflammatory disorder confined to colon and rectum

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2
Q

caused by

A
  • genetics

- NSAIDs

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3
Q

what decreases risk

A

smoking

appendectomy

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4
Q

what is it called when it just affects rectum

A

proctitis

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5
Q

what is it called when it affects whole colon

A

extensive colitis

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6
Q

what does mucosa look like

A

red and inflamed

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7
Q

does mucosa bleed easily

A

yes

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8
Q

are polyps present

A

yes

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9
Q

is there ulceration

A

yes

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10
Q

can the mucosa return. to normal

A

yes but scarring likely

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11
Q

what is there a depletion of

A

goblet cells

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12
Q

what are serological test for

A

anti-neutrophil cytoplasmic antibodies (ANCA)

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13
Q

what is main symptom

A

diarrhoea with blood and mucus

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14
Q

Where is there discomfort

A

lower abdomen

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15
Q

what are general features

A
  • malaise
  • lethargy
  • anorexia
  • weight loss
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16
Q

what is proctitis characterised by

A

frequent passage of blood and mucus

17
Q

symptoms of an acute attack on left side

A

bloody diarrhoea passing up to 10-20 liquid stools a day

18
Q

what is a serious complication

A

toxic megacolon

19
Q

what’s required for toxic megacolon

A

urgent surgery

20
Q

what is rectal exam shows

A

blood

21
Q

pANCA result

A

positive

22
Q

what is gold standard

A

colonoscopy

23
Q

1st line treatment

A

5 ASA

24
Q

is onset fast or slow

A

fast - number of weeks

25
Q

are granulomas present

A

no

26
Q

are crypts regular

A

no - irregular

27
Q

what are at the base of crypts

A

plasma cells

28
Q

complications

A
  • toxic megacolon
  • colorectal carcinoma
  • primary sclerosing cholangitis
  • blood loss
29
Q

what is required for toxic megacolon

A

surgical emergency

30
Q

what scoring system is used

A

MUST score

31
Q

what antibodies are checked for

A

pANCA

32
Q

what would be seen on endoscopy

A

psuedopolyps

33
Q

what is given for a flare up

A

prednisolone

34
Q

what has to be monitored in azathioprine

A
  • bone marrow suppression
  • hepatitis
  • pancreatitis