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Flashcards in Unit 7 Deck (86)
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1

DNA and RNA purines

Adenine

Guanine

2

RNA pyrimidines

Cytosine

Uracil

3

DNA pyrimidines

Thymine

Cytosine

4

Difference between purines and pyrimidines

Purines have 2 rings

Pyrimidines have only 1

5

Nucleosides end will end in

-one

6

Nucleotides will end in:

-late

7

What can synthesize nucleotides in the de novo pathway?

Amino acids

Ribose-5-phosphate,

CO2

NH3

8

In the salvage pathway, nucleotides can be salvages from _______ released from the breakdown of:

Nucleobases

Nucleic acids

9

Compounds that inhibit ______ pathways are promising anti-parasite drugs

Salvage

10

In purine de novo biosynthesis, bases are synthesized while attached to:

Ribose

11

In pyrimidine de novo biosynthesis, only (BEFORE/AFTER) complete synthesis of bases, they are attached to what?

Before

Activated sugar 5-phosphoribosyl-1-pyrophosphate (PRPP)

12

Site of purine synthesis

Liver

13

Amino acids in purine ring

Glycine

Aspartate

Glutamine

14

Major contributors of purine ring

Amino acids

CO2

N10- formyl THFf

15

End products of de novo purine biosynthesis

Ribonucleotides

16

Activator or PRPP synthetase

Pi

17

Inhibitors of PRPP synthetase

Purine

Ribonucleotides

18

De novo biosynthesis of purines begins with:

PRPP with glutamine

19

During de novo biosynthesis of purines, what are synthesized as AMP and GMP?

Adenine and guanine

20

In de novo biosynthesis of purines, the ring builds up following the addition of:

3 atoms from glycine

21

What is the first intermediate with a full purine ring?

Inosin monophosphate (IMP) or inosinate

22

Intermediate needed for Inosinate to adenylosuccinate

Adenylosuccinate synthetase

23

What enzymes are needed for IMP - adenylosuccinate

Aspartate and GTP

24

Intermediate for IMP to XMP (xanthylate)

IMP dehydrogenase

25

Enzymes needed for IMP- XMP

H2O,

NAD+

26

To make GMP, inosinate is deoxidized to _______,

This then takes on intermediate ________, with enzymes ___ and ______ to GMP

Xanthylate

XMP-glutamamine aminotransferase

Glen
ATP

27

Site of nucleic acid degradation

Gut

28

In the stomach, what denatures nucleic acid?

Low pH

29

What hydrolysis nucleic acids to nucleotides?

Pancreatic nucleases

30

Intestinal mucosal cells derived nucleotides ________ nucleotides to nucleosides

Dephosphorylate