Flashcards in Unit 7 Deck (86)
DNA and RNA purines
Difference between purines and pyrimidines
Purines have 2 rings
Pyrimidines have only 1
Nucleosides end will end in
Nucleotides will end in:
What can synthesize nucleotides in the de novo pathway?
In the salvage pathway, nucleotides can be salvages from _______ released from the breakdown of:
Compounds that inhibit ______ pathways are promising anti-parasite drugs
In purine de novo biosynthesis, bases are synthesized while attached to:
In pyrimidine de novo biosynthesis, only (BEFORE/AFTER) complete synthesis of bases, they are attached to what?
Activated sugar 5-phosphoribosyl-1-pyrophosphate (PRPP)
Site of purine synthesis
Amino acids in purine ring
Major contributors of purine ring
N10- formyl THFf
End products of de novo purine biosynthesis
Activator or PRPP synthetase
Inhibitors of PRPP synthetase
De novo biosynthesis of purines begins with:
PRPP with glutamine
During de novo biosynthesis of purines, what are synthesized as AMP and GMP?
Adenine and guanine
In de novo biosynthesis of purines, the ring builds up following the addition of:
3 atoms from glycine
What is the first intermediate with a full purine ring?
Inosin monophosphate (IMP) or inosinate
Intermediate needed for Inosinate to adenylosuccinate
What enzymes are needed for IMP - adenylosuccinate
Aspartate and GTP
Intermediate for IMP to XMP (xanthylate)
Enzymes needed for IMP- XMP
To make GMP, inosinate is deoxidized to _______,
This then takes on intermediate ________, with enzymes ___ and ______ to GMP
Site of nucleic acid degradation
In the stomach, what denatures nucleic acid?
What hydrolysis nucleic acids to nucleotides?