VI - Hematologic System Flashcards Preview

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Flashcards in VI - Hematologic System Deck (43)
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1

Vehicle that transports gases, nutrients, hormones and metabolic wastes, regulates pH and ion concentration of interstitial fluids, defense against towins and pathogens, stabilizes body temperature

blood

2

Fluid medium of blood, non-celuular, suspends cells

plasma

3

Plasma minus clotting factors

Serum

4

Composition of Plasma

water (90%), plasma protein (8%), inorganic salts (1%), lipids (0.5%), sugar (0.1%)

5

Process of forming blood cells in the bone marrow

Haemopoiesis

6

Site of blood cell formation beginning from the 3rd week AOG

yolk sac / Aortic Gonad Mesonephros (AGM) Region

7

Site of blood cell formation from the 3rd month AOG to birth

liver (with minor contributions from the spleen and LN)

8

Only source of blood cells postnatally, begins at the 4th month AOG

bone marrow

9

Hematopoiesis: all bone marrow are active

birth to puberty

10

Hematopoiesis: only bone marrow of the vertebra, ribs, sternum, skull, pelvis, proximal epiphyseal region of humerus are active

20 y.o. (fatty, yellow, inactive marrow)

11

Hematopoiesis: post-embryonic extramedullary hematopoiesis in a full-term infant is always

abnormal

12

Most abundant blood cells, gives blood its characteristic functions

Erythrocytes (RBCs)

13

Transports hemoglobin (carries oxygen) from the lungs to tissues for use, transports CO2 (HCO3) from tissues to the lungs for expulsion, acts as an acid-base buffer for the blood (carbonic anhydrase)

Erythrocytes (RBCs)

14

Catalyzes the reaction between CO2 and H2O to form carbonic acid (H2CO3)

Carbonic Anhydrase

15

Normal RBC Shape

biconcave disc with bag pliability

16

Creates the biconcave shape of RBCs

spectrin

17

RBCs have a _____ ration of SA to volume.

large SA:V

18

RBCs form _____ for smoother flow.

stacks

19

Protein inside the RBC that binds with oxygen

Hemoglobin

20

Normal Hemoglobin Levels

Males: 14-18 g/dL, Females: 12-18 g/dL

21

Percent of cells in whole blood

Hematocrit

22

Normal Hematocrit Levels

Males: 46 (40-54), Females: 42 (37-47)

23

Composed of 4 polypeptide subunits (2 alpha, 2 beta), transports 97% of oxygen

Hemoglobin

24

2 Succinyl-CoA + 2 Glycine

Pyrrole

25

Protoporphyrin IX + Fe2+

Heme

26

Heme + Polypeptide

Hemoglobin Chain

27

2 α-chains + 2 β-chains

Hemoglobin A

28

Hemoglobin: most common form of in adults

Hemoglobin A (2α2β)

29

Hemoglobin: has a higher affinity for O2 compared to HbA

Hemoglobin F (2α2γ)

30

Essential metallic component of heme

Iron