Vibrio cholerae

Question 1

shape

Answer 1

gram (-) curved rods

Question 2

most common source of vibrio cholerae

Answer 2

fecally contaminated water

Question 3

cholera

Answer 3

secretory diarrhea (non-invasive)

Question 4

cholera toxin

Answer 4

A-B toxin
* A subunit locks a stimulatory regulatory G protein in the “actie” mode, turning on adenylate cyclase
* Adenylate cyclase causes the conversion of ATP to cAMP
* cAMP acitvates activates ion transport channels in the membrane causing Cl- and other electrolytes to pour of hte cell
* water follows electrolytes out of the cell by osmosis

Question 5

signs and symptoms

Answer 5

copious amounts of watery stool caled “rice water” stool

Question 6

cholera in children

Answer 6

dehydration –> lethargic, suken eyes, flaccid skin –> hypovolemic shock –> death