VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Preview

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Flashcards in VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Deck (225)
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151

Inhibits guanosine triphosphate formation, prevents capping of viral mRNA, blocks RNA-dependent RNA polymerase, inhibit replication of many DNA and RNA viruses like Influenza A and B, parainfluenza, paramyxo viruses, HCV and HIV

Ribavirine (TOPNOTCH)

152

For HCV infection (with IFN ) and RSV infection, decreasesmortality in viral hemorrhagic fevers

Ribavirine (TOPNOTCH)

153

Prevents polymerization of heme into hemozoin, blood schizonticide

Chloroquine, hydroxychloroquine (TOPNOTCH)

154

Complexes with DNA to prevent strand separation, blocks DNA replication and transcription, blood schizonticide

Quinine, quinidine gluconate (TOPNOTCH)

155

DOC for malaria in pregnant patients

Quinine, quinidine gluconate (TOPNOTCH)

156

1st line drug (weekly administration) for prophylaxis in all areas with Chloroquine resistance)

Mefloquine (TOPNOTCH)

157

Forms electron-transferring redox compounds that act as cellular oxidants, tissue schizonticides, gametocides

Primaquine (TOPNOTCH)

158

Eradicates hypnozoites in the liver, preventing malarial relapse

Primaquine (TOPNOTCH)

159

______ disrupts mitochondrial electron transport, blood and tissue schizonticide, ______ inhibits folate synthesis, sporonticide

Atovaquone-proguanil (TOPNOTCH)

160

also effective against Mefloquine-resistant Falciparum infection

Atovaquone-proguanil (TOPNOTCH)

161

_____ is the DOC for uncomplicated falciparum malaria in the Philippines

Co-artem (TOPNOTCH)

162

DOC for asymptomatic cyst carrier of E. histolytica

Diloxanide Furoate (TOPNOTCH)

163

Inhibits protein synthesis, blocks ribosomal movement along messenger RNA, tissue amebicide ; back up drug for severe intestinal and extraintestinal amebiasis

Emetine, dehydroemetine (TOPNOTCH)

164

Inhibits protein synthesis, binds to 16S ribosomal subunit, luminal amebicide ; For intestinal amebiasis, cryptosporidiosis

Paromomycin (TOPNOTCH)

165

For metronidazole-resistant amebiasis, giardiasis, cryptosporidiosis (DOC)

Nitazoxanide (TOPNOTCH)

166

For prophylaxis and treatment of pneumocystosis (DOC), prophylaxis (T. gondii, I. belli)

Co-trimoxazole (TOPNOTCH)

167

For prophylaxis and treatment of toxoplasmosis (DOC)

Pyrimethamine-sulfadiazine (TOPNOTCH)

168

alternative drug for Toxoplasmosis is _____

Clindamycin (TOPNOTCH)

169

For African sleeping sickness (hemolymphatic stage),onchocerciasis (backup)

Suramin (TOPNOTCH)

170

Suicide inhibitor of ornithine decarboxylase; For advanced west African sleeping sickness (DOC)

Eflornithine (TOPNOTCH)

171

Organic arsenical, inhibits enzyme sulfhydryl groups in trypanosomes; DOC for African sleeping sickness

Melarsoprol (TOPNOTCH)

172

Inhibits trypanothione reductase; DOC for Chagas disease (Trypanosoma cruzi)

Nifurtimox (TOPNOTCH)

173

DOC for Leishmaniasis

Sodium Stibogluconate (TOPNOTCH)

174

Selectively inhibits microtubule synthesis and glucose uptake in nematodes, ovicidal ; For ascariasis, pinworm, whipworm

Mebendazole (TOPNOTCH)

175

Inhibits microtubule assembly, larvicidal and ovicidal ; For ascariasis, hookworm, whipworm, hydatid disease (DOC), threadworms, filariasis, larva migrans, cysticercosis

Albendazole (TOPNOTCH)

176

primary drug for ascariasis, ancylostomiasis, trichuriasis

Albendazole (TOPNOTCH)

177

DOC for filariasis and eye worm disease

Diethylcarbamazine (TOPNOTCH)

178

May cause mazzotti reaction when used for onchocerciasis

Diethylcarbamazine (TOPNOTCH)

179

Intensifies GABA-mediated neurotransmission in nematodes, immobilizes parasites ; DOC for strongyloidiasis

Ivermectin (TOPNOTCH)

180

Stimulates nicotinic receptors at NMJ of nematodes, causes depolarization-induced paralysis

Pyrantel pamoate (TOPNOTCH)