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Path: Infectious Disease > Virus1 > Flashcards

Virus1 Flashcards

1
Q

these are essential to prevent viremia

A

antibodies

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2
Q

these cells attack virally infected cells w/ decreased MHC class 1 expression

A

NK

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3
Q

this mediates lysis of virus infected cells in CMI

A

CD8 (CD4 necessary for initial reaction)

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4
Q

cytoplasmic inclusion bodies in Purkinje cells in rabies

A

negri bodies

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5
Q

this virus has both nuclear and cytoplasmic inclusion bodies

A

CMV

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6
Q

this cytoplasmic change seen in papilloma virus

A

Koliocytosis

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7
Q

infiltrate in viral response

A

perivascular mononuclear (lymphocytes and MP)

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8
Q

causes most cases of rabies worldwide (especially in Mexico and Middle East)

A

wild dogs

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9
Q

receptor for EBV on MP

A

CD21 complement receptor

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10
Q

rabies attaches to this kind of receptor

A

Ach

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11
Q

receptor for rhinovirus

A

ICAM-1

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12
Q

cell required for JC virus

A

oligodendroyctes

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13
Q

kind of inflammation seen in viral infection

A

lymphocytic (w or w/o necrosis)

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14
Q

these present target antigens of virus on host infected cell

A

MHC class I

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15
Q

in cell mediated response to viral infection…inhibits RNA translation –> effects viral translation more than host functions

A

g-interferons

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16
Q

in cell mediated response to viral infection…activates antiviral responses

A

a, B interferons

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17
Q

these are antiviral cytokines

A

a, B, g interferons

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18
Q

HIV and EBV disseminate via this

A

lymphoid

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19
Q

3 features that determine pathology of viral illness

A

distribution, cytopathic features, host immune reaction

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20
Q

inclusion bodies in herpes and varicella

A

Cowdry type A intranuclear

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21
Q

inclusion bodies in rabies

A

cytoplasmic negri bodies

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22
Q

inclusion bodies in papillomavirus

A

koliocytes

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23
Q

inclusion bodies in hepatitis

A

Councilman bodies

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24
Q

this virus has Councilman bodies (necrotic cells)

A

hepatitis

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25
giant cells seen in measles
Warthin-Finkeldey (with intracytoplasmic/intranuclear inclusion bodies)
26
inclusion bodies seen in adenovirus
smudge cells and Cowdry type A (intranuclear)
27
see ground glass cytoplasm in this viral infection
hepatitis
28
do you see abscesses in viral infection?
no
29
what is reservoir for childhood illness viruses (CP/MMR)
human
30
transmission for CP/MMR
respiratory drop nuclei
31
when do CP/MMR cases peak during the year?
late winter and spring
32
where does varicella/MMR replicate?
nasopharynx and regional LN
33
typical incubation period for Varicella
14-16 days
34
where does Varicella rash typically begin? where is it concentrated after spread?
head; trunk
35
successive crops of these occur every 2-4 days in Varicella infection
pruritic vesicles
36
how long does mild prodrome last in Varicella infection?
1-2 days
37
possible complications for Varicella infection
secondary bacterial infection (of vesicle), CNS manifestations, pneumonia (rare in children)
38
groups of patients that are at risk of increased complications in Varicella infection
normal adults, immunocompromised persons, newborns
39
if mom gets rash in this time period from delivery, her newborn is at high risk of Varicella/complications of infection
5 days before or 48 hours after
40
this occurs as result of reactivated Varicella zoster virus
herpes zoster
41
virus responsible for chicken pox
Varicella
42
latent infection of these with Varicella seen in Herpes zoster
sensory ganglia
43
most frequent distribution of lesions in herpes zoster
trigeminal nerve
44
herpes zoster associated with these risk factors
aging, immunosuppression, intrauterine exposure, Varicella
45
when does primary viremia due to measles exposure occur? when does secondary viremia occur? (time after exposure of virus)
2-3 days; 5-7 days
46
incubation period for measles
10-12 days
47
3 C of measles symptoms
cough, coryza, conjunctivitis (also stepwise increase in fever to 103)
48
symptoms of measles prodromal stage
fever (up to 103 or higher), cough, coryza, conjunctivitis, Koplik spots
49
time it takes for rash to develop after prodrome in measles infection; how long is this after exposure?
2-4 days; 14 days
50
kind of rash measles has
maculopapular
51
how long does measles rash last?
5-6 days
52
these are associated with lymphoid hyperplasia in measles infection
warthin-finkeldy multinucleated giant cells
53
possible dangerous complication of measles infection
sub-acute sclerosing pan encephalitis
54
aka the "German" or "3 day measles"
rubella
55
viremia in rubella occurs this many days after exposure (spread to tissues)
5-7 days
56
incubation period for rubella
14 days (12-23)
57
symptoms of prodromal stage of rubella infection
low grade fever, lymphadenopathy (in second week)
58
description of rash in rubella; when does it occur after exposure?
maculopapular; 14-17 days
59
major symptoms of congenital rubella syndrome (TORCH)
deafness, cataracts, heart defects, mental retardation
60
viremia in mumps occurs this time frame after exposure
12-25 days
61
incubation period for mumps
14-18 days
62
will see this complication/symptom in mumps infection in 30-40% of patients
parotitis
63
mumps may present as this in preschool aged children
LRT infection
64
acute viral illness with parotitis and orchitis (20-50% post-pubertal males)
mumps
65
recommended age/minimum age for MMR vaccine
12 months
66
second dose for MMR a this age
4-6 years
67
contraindications for MMR vaccine
pregnancy, immunosuppression (OK for asymptomatic/mildly symptomatic HIV), acute illness, recent blood product
68
complications of mumps infection
orchitis/sterility, encephalitis
69
virus used in small pox vaccination
vaccinia
70
mode of transmission for small pox
prolonged face-to-face contact, direct contact w/ body fluids (rare aerosolization)
71
incubation period for small pox
12-14 days
72
how long does prodrome period of small pox last (fever, malaise, body aches, vomiting)?
2-4 days
73
where does small pox rash begin (lesions ulcerate then release virions)?
tongue and mouth
74
where does small pox rash spread after it starts on face?
arms, legs, hands, feet (then to rest of body in 24 hours)

Path: Infectious Disease (10 decks)

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