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Path: Infectious Disease > Virus2 > Flashcards

Virus2 Flashcards

1
Q

minor diseases caused by non-polio enterovirus

A

URT and GI infection

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2
Q

serious complications of non-polio enterovirus

A

aseptic meningitis, encephalitis, myocarditis (coxsackie virus B)

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3
Q

when are non-polio enterovirus most common? how are they transmitted?

A

fall/summer; respiratory secretions or fecal-oral

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4
Q

this non-polio enterovirus causes myocarditis/pericarditis

A

coxsackie B

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5
Q

genome for coxsackie virus

A

ssRNA

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6
Q

this non-polio enterovirus is most closely associated with juvenile diabetes

A

coxsackie

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7
Q

characterized by vesicles in mouth (looking similar to herpes) –> caused by coxsackie virus

A

herpangina

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8
Q

infiltrate seen in myocarditis due to coxsackie B infection

A

lymphocytic

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9
Q

organism that most commonly causes hand, foot, and mouth disease

A

coxsackie virus A16

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10
Q

incubation period for HFM disease

A

3-7 days

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11
Q

this causes fifth disease *erythema infectiosum* –> slapped cheek rash, lacy red rash on trunk/limbs

A

parvovirus B19

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12
Q

slapped cheek rash, lacy red rash on trunk/limbs (may itch) –> associated with *aplastic anemia*

A

erythema infectiosum

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13
Q

major complication of erythema infectiosum due to parovirus B19 associated with sickle cell, other chronic diseases or immunosuppression (may be irreversible)

A

aplastic anemia

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14
Q

these non-polio enteroviruses resemble rubella (*important to distinguish from rubella so we know if there is outbreak to protect pregnant women*)

A

erythema infectiosum and roseola infantum

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15
Q

two major diagnostic criteria for roseola infantum

A

high fever and infant

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16
Q

polio enterovirus infects this tissue

A

oropharynx

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17
Q

this is inactive polio virus vaccine; requires booster, no risk of paralytic disease

A

salk

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18
Q

attenuated polio virus vaccine; risk of paralytic disease (especially Immunocompromised), greater duration immunity (induction IgA immunity in GI)

A

sabin

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19
Q

viruses that cause UR viral syndrome

A

adenovirus, rhinovirus, echovirus, coronavirus

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20
Q

viruses that cause LR viral syndrome

A

influenza, parainfluenza, RSV

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21
Q

viruses that cause GI tract/liver viral syndrome

A

rotavirus, norwalk, hepatitis

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22
Q

inclusions that are seen in adenovirus

A

cowdry type A intranuclear

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23
Q

only RNA virus that causes cancer (*due to chronic inflammation*)

A

hepatitis C

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24
Q

what does HSV I cause?

A

gingivostomatitis and cold sores (reactivation)

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25
diagnostic procedure for herpes; what does this reveal if herpes present?
Tzacnk prep; inclusion-bearing multinucleated syncytia (giant cells)
26
these pathological features are associated with blisters/vesicles in herpes
edema and ballooning degeneration
27
this is major infectious cause of corneal blindness....also causes fatal sporadic encephalitis and can cause disseminated disease in immunocompromised
HSV1
28
symptoms caused by herpes TORCH infection
blindness, deafness, ataxia
29
herpes vesicles on fingers
herpetic whitlow
30
latent infections of EBV
Burkitt's lymphoma, B cell lymphoma, Nasopharyngeal carcinoma, sarcoidosis
31
this disease will cause false positive mono-spot test (because does polyclonal activation B cells)
lupus
32
these lymph nodes involved in enlargement and tenderness in infectious mono
cervical
33
EBV binds to complement receptor on these cells
epithelial cells and B cells
34
atypical lymphocytes in infectious mono
suppressor T cells
35
these 3 things necessary for diagnosis of infectious mono
atypical lymphocytes, positive heterophile reaction, Ab for EBV
36
most common opportunistic viral disease in AIDS patients
CMV
37
aka genital warts
Condyloma accuminatum
38
this virus causes Kaposi's sarcoma
HHV8
39
genome for HSV I/II
ds DNA
40
these complications seen more commonly in older patients infected with infectious mono (EBV)
hepatitis, meningoencephalitis, pneumonitis
41
EBV binds complement receptor on epithelial and B cells --\> spread thru oral epithelium to what?
B lymphoid tissues
42
see this in infectious mono due to the lymphoproliferation
lymphocytosis
43
when do heterophile Ab (agglutinate RBC) peak in infectious mono? how long are they present?
2-3 weeks; 2-9 mo
44
are heterophile Ab seen in infectious mono specific for EBV?
no (polyclonal activation)
45
helps in diagnosis of CMV infection in neonates
CMV infected cells in urine sediment
46
CMV infection is almost always accompanied by this infection in AIDS
Pneumocystis carinii
47
CMV in immunosuppressed is associated with reactivation of viral infection that was latent in these cells
leukocytes
48
HPV initially infects these cells
basal cells
49
non-neoplastic strains of HPV associated with this
koliocytosis
50
this virus is associated with multihemorrhagic manifestations, DIC, shock, death 30-90% --\>death from hemorrhage, shock, fluid loss (although there is some visceral organ necrosis also)
ebola
51
which neoplastic virus is considered nosocomial?
ebola
52
this virus is transmitted to humans through rodent urine or feces --\> acute hemorrhagic pulmonary syndrome (\*mortality 50%\*) --\> fever, ARDS, hemorrhages, DIC
hanta
53
this virus is transmitted thru Aedes mosquito --\> causes hemorrhagic fever, thrombocytopenia, but more commonly myalgias, arthralgias, rash, NVD, fever, headache
dengue
54
short-lived condition caused by WNV; what does it progress to in 1/150 infected individuals?
febrile illness (HA and myalgia); meingitis/encephalitis/meningoencephalitits
55
these types of coxsackie virus cause viral meingitis, myocarditis/pericarditis (B only), herpangina, and acute onset juvenile diabetes
A23 and B6
56
rash seen with Hand, Foot, Mouth disease
maculopapular, soles/palms, sometimes vesicles
57
this is responsible for roseola infantum
HHV-6
58
infant, high fever, lymphocytes w/ intranuclear inclusion bodies in CSF, maculopapular rash a few days following
roseola infantum
59
inclusion bodies seen in Roseola infantum
intranuclear (in lymphocytes)
60
where does polio (nonenveloped RNA) replicate initially?
intestinal mucosa and lymph nodes (1% invade CNS and multiply in motor neurons causing paralysis)
61
receptors for polio virus
Ig superfamily
62
these are responsible for hypersecretion seen in rhinovirus infection
bradykinins and inflammatory response
63
these nonpolio enteroviruses spread oral-fecal, disseminate in blood after proliferation in lymphoreticular tissue, and primarily cause respiratory disorders
echovirus and coxsackie
64
this protein on influenza binds to sialic acid containing proteins and lipids on most cells (mediates entry)
hemagglutinin
65
infiltrate of submucosa seen in influenza virus infection
lymphomonocytic and plasmacytic
66
causes croup (acute laryngotracheobronchitits)
parainfluenza 3
67
most common cause of viral pneumonia in children
RSV
68
these are seen within alveoli in RSV pneumonia infection
alveolar MP
69
inclusions seen in adenovirus
Cowdry type A intranuclear
70
common cause of ARDS and pneumonia in military recruits
adenovirus
71
these cause pneumonias in immunosuppressed
CMV, varicella, HSV
72
infectious diarrhea in infants/children --\> most common in children being weaned (not getting mother's IgA through milk anymore) --\> destroys host epithelial cells
rotavirus

Path: Infectious Disease (10 decks)

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