Flashcards in Viruses Deck (14):
1
Human Papillomavirus
Family
Enveloped?
Genome
#serotypes
Papvaviridae family
Non-enveloped
dsDNA genome
>100 serotypes
2
Which HPV serotypes cause common warts?
Which HPV serotypes cause plantar warts?
Common: HPV 2, 3, and 10
Plantar: HPV 1 and 4
3
Molluscum Contagiosum
Virus
Family
Genome
Location of Replication
Molluscum contagiosum virus
Poxviridae family
Large, dsDNA genome
Replicates in cytoplasm
4
HSV
Family
Enveloped?
Genome
Herpesviridae family
Enveloped
dsDNA genome
5
Chickenpox Virus
Family
Enveloped?
Genome
#Serotypes
Varicella-Zoster Virus
Herpesviridae family
Enveloped
dsDNA genome
1 serotype
6
Varicella vaccine:
Prevents what infections?
Dead? live? weakened?
Dose timing (2)
1. Prevent primary infections with VZV
2. Live attenuated
3. Dose 1 at 12-15months. Dose 2 at 4-6 years
*Combined with MMR to make MMRV since 2005
7
Zoster vaccine
Protection from what?
What is different from Varicella vaccine?
Recommended for who?
1. Protects against VZV reactivations
2. Same live attenuated strain as varicella but with higher titer
3. Recommended for all adults over 60, regardless of whether or not they have had previous episode of zoster
8
Smallpox
Virus
Family
Genome
Location of replication
Variola virus
Poxviridae family
Large, dsDNA genome
Replicates in cytoplasm
9
Variola Virus Vaccine
What is it? State of virus? Which virus?
Contemporary vaccine consists of a live strain of a vaccinia virus
10
Measles Virus:
Family
Genome
Enveloped?
Two important genes and their protein functions
#Antigens
Paramyxovirus
-ssRNA genome
Enveloped
F gene- fusion
HA (hemeagglutin)- attachment
1 antigenic type
11
Measles vaccine:
Live? dead? weakened?
Prepared in what?
Combined with which other vaccines?
Dose timing (2)
Live, attenuated
Prepared in fibroblasts of chick embryos
MMR, MMRV
1st dose: 12-15months
2nd dose: 4-6 years
12
Rubella Virus:
Family
Enveloped?
Genome
Vaccine: state of virus
Purpose of vaccine
Togaviridae family
Enveloped
+ssRNA genome
Live, attenuated vaccine
Prevent congenital rubella syndrome
13
Fifth Disease
Causative virus
Family
Genome
B19 Parvovirus
Parvoviridae family
ssDNA genome
14