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Flashcards in Viruses Deck (14):
1

Human Papillomavirus
Family
Enveloped?
Genome
#serotypes

Papvaviridae family
Non-enveloped
dsDNA genome
>100 serotypes

2

Which HPV serotypes cause common warts?
Which HPV serotypes cause plantar warts?

Common: HPV 2, 3, and 10
Plantar: HPV 1 and 4

3

Molluscum Contagiosum
Virus
Family
Genome
Location of Replication

Molluscum contagiosum virus
Poxviridae family
Large, dsDNA genome
Replicates in cytoplasm

4

HSV
Family
Enveloped?
Genome

Herpesviridae family
Enveloped
dsDNA genome

5

Chickenpox Virus
Family
Enveloped?
Genome
#Serotypes

Varicella-Zoster Virus
Herpesviridae family
Enveloped
dsDNA genome
1 serotype

6

Varicella vaccine:
Prevents what infections?
Dead? live? weakened?
Dose timing (2)

1. Prevent primary infections with VZV
2. Live attenuated
3. Dose 1 at 12-15months. Dose 2 at 4-6 years
*Combined with MMR to make MMRV since 2005

7

Zoster vaccine
Protection from what?
What is different from Varicella vaccine?
Recommended for who?

1. Protects against VZV reactivations
2. Same live attenuated strain as varicella but with higher titer
3. Recommended for all adults over 60, regardless of whether or not they have had previous episode of zoster

8

Smallpox
Virus
Family
Genome
Location of replication

Variola virus
Poxviridae family
Large, dsDNA genome
Replicates in cytoplasm

9

Variola Virus Vaccine
What is it? State of virus? Which virus?

Contemporary vaccine consists of a live strain of a vaccinia virus

10

Measles Virus:
Family
Genome
Enveloped?
Two important genes and their protein functions
#Antigens

Paramyxovirus
-ssRNA genome
Enveloped
F gene- fusion
HA (hemeagglutin)- attachment
1 antigenic type

11

Measles vaccine:
Live? dead? weakened?
Prepared in what?
Combined with which other vaccines?
Dose timing (2)

Live, attenuated
Prepared in fibroblasts of chick embryos
MMR, MMRV
1st dose: 12-15months
2nd dose: 4-6 years

12

Rubella Virus:
Family
Enveloped?
Genome
Vaccine: state of virus
Purpose of vaccine

Togaviridae family
Enveloped
+ssRNA genome
Live, attenuated vaccine
Prevent congenital rubella syndrome

13

Fifth Disease
Causative virus
Family
Genome

B19 Parvovirus
Parvoviridae family
ssDNA genome

14

Roseola Infantum
Causative viruses (2)
Family
Genome
Enveloped
Replicates in which cells?
Latent in which cells?

HHV 6 and 7*
Herpesviridae family
dsDNA genome
Enveloped
Replicates in B cells, T cells, and oral pharynx
Latent in T cells
*HHV 7 operates only in CD4+ T cells