Viruses

Question 1

Human Papillomavirus
Family
Enveloped?
Genome
#serotypes

Answer 1

Papvaviridae family
Non-enveloped
dsDNA genome
>100 serotypes

Question 2

Which HPV serotypes cause common warts?

Which HPV serotypes cause plantar warts?

Answer 2

Common: HPV 2, 3, and 10
Plantar: HPV 1 and 4

Question 3

Molluscum Contagiosum
Virus
Family
Genome
Location of Replication

Answer 3

Molluscum contagiosum virus
Poxviridae family
Large, dsDNA genome
Replicates in cytoplasm

Question 4

HSV
Family
Enveloped?
Genome

Answer 4

Herpesviridae family
Enveloped
dsDNA genome

Question 5

Chickenpox Virus
Family
Enveloped?
Genome
#Serotypes

Answer 5

Varicella-Zoster Virus
Herpesviridae family
Enveloped
dsDNA genome
1 serotype

Question 6

Varicella vaccine:
Prevents what infections?
Dead? live? weakened?
Dose timing (2)

Answer 6

1. Prevent primary infections with VZV
2. Live attenuated
3. Dose 1 at 12-15months. Dose 2 at 4-6 years
   * Combined with MMR to make MMRV since 2005

Question 7

Zoster vaccine
Protection from what?
What is different from Varicella vaccine?
Recommended for who?

Answer 7

1. Protects against VZV reactivations
2. Same live attenuated strain as varicella but with higher titer
3. Recommended for all adults over 60, regardless of whether or not they have had previous episode of zoster

Question 8

Smallpox
Virus
Family
Genome
Location of replication

Answer 8

Variola virus
Poxviridae family
Large, dsDNA genome
Replicates in cytoplasm

Question 9

Variola Virus Vaccine

What is it? State of virus? Which virus?

Answer 9

Contemporary vaccine consists of a live strain of a vaccinia virus

Question 10

Measles Virus:
Family
Genome
Enveloped?
Two important genes and their protein functions
#Antigens

Answer 10

Paramyxovirus
-ssRNA genome
Enveloped
F gene- fusion
HA (hemeagglutin)- attachment
1 antigenic type

Question 11

Measles vaccine:
Live? dead? weakened?
Prepared in what?
Combined with which other vaccines?
Dose timing (2)

Answer 11

Live, attenuated
Prepared in fibroblasts of chick embryos
MMR, MMRV
1st dose: 12-15months
2nd dose: 4-6 years

Question 12

Rubella Virus:
Family
Enveloped?
Genome
Vaccine: state of virus
Purpose of vaccine

Answer 12

Togaviridae family
Enveloped
\+ssRNA genome
Live, attenuated vaccine
Prevent congenital rubella syndrome

Question 13

Fifth Disease
Causative virus
Family
Genome

Answer 13

B19 Parvovirus
Parvoviridae family
ssDNA genome

Question 14

Roseola Infantum
Causative viruses (2)
Family
Genome
Enveloped 
Replicates in which cells?
Latent in which cells?

Answer 14

HHV 6 and 7*
Herpesviridae family
dsDNA genome
Enveloped
Replicates in B cells, T cells, and oral pharynx
Latent in T cells
*HHV 7 operates only in CD4+ T cells