Vitamin K Flashcards Preview

Nutrition 1 Part 2 > Vitamin K > Flashcards

Flashcards in Vitamin K Deck (37):
1

three souces of vitamin K

phylloquinone (K1)
menaquinone (K2)
menadione (K3)

2

Phylloquinone (K1) is synthesized from

plants

3

menaquinone (K2) is synthesized from

animal sources

4

menadione (K3) is synthesized from

synthetic

5

vitamin k is destroyed by

light and heat

6

Vitamin K is ______ and requires bile for micelle formation

fat soluble

7

absorption of vitmain K is enhanced by the presence of

fat
bile salts
pancreatic juices

8

phylloquinone (K1) is absorbe in the

small intestine (jejun)

9

menaquinons are synthesized by bacteria in the_____ and absorbed by_____

lower digestive tract
passive diffusion

10

phylloquinone or menaquinone is absorbed better

menaquinone

11

vitamin k is incorporated into____ for transport across tissues

chylomicron

12

once vitamin k is incorporated into chylomicron, its is delivered to:

liver

13

Vitamin K can be incorporated into ____ for transport to extra hepatic tissue

VLDL

14

vitamin k is primarily stored in the

liver

15

the primary function of vitamin k is to :

serve as the cofactor for a carboxylase enzyme that catalyzes the g-carboxylation of glutamic acid (Glu) residues on specific proteins

16

the conversion of Glu residues to g-carboxyglutamate activates these proteins by creating what

calcium binding sites

17

g-carboxylation of glutamic acid residues is required for the activation of 7 proteins that regulate what

coagulation of blood in the clotting cascade

18

what are the four clotting factors

II
VII
IX
X

19

what are the three anticoagulant proteins

C
S
Z

20

three vitamin k depends proteins have been identified where

bone
cartilage
dentine

21

metabolites of vitamin k are excreted

primarily in the feces via bile

22

vitamin k deficiency results in

impaired blood clottin

23

symptoms of impaired blood clotting

easy bruise, bleeding gums, hematuria, blood in stool, nosebleeds

24

vitamin k deficiency is uncommon in adults for what three reasons

vitamin k is widespread in food
the vitamin k cycle conserves vitamin k
bacteria that normal inhabit the LI synthesize menaquinones (K2)

25

greatest risk for deficiency in adults

liver disease
fat malabsorptive disorders
chronic antibiotic use

26

why is the risk of deficiency worse in newborns

-vitamin k is no easily transported across placental border
-newborns intestines are not yet colonized with bacteria that synthesize menaquinones
- vitamin k cycle is not fully working
- breast milk has poor vitamin k content

27

vitamin k in infants may result in

vitamin k deficiency bleeding - life threatening

28

how is VKDB treated at birth

vitamin k shot

29

clinical indication of vitamin k supplementation

osteoporosis
atherosclerosis

30

which two are not associated with toxicity
phylloquinone
menaquinone
menadione

phylloquinone
menaquinone

31

menadioine may cause

liver toxcity and hemolytic anemia

32

vitamin k supplementation should have caution with patients on what drug

warfarin (coumadin)

33

why should there be caution on patients taking coumadin

coumadin prevents the recycling of vitamin k by inhibiting two important reactions and creating a functional deficiency

34

increasing vitamin k intake _____ action of coumadin

inhibits

35

increasing intake of coumadin _____ action of vitamin k

inhibits

36

Vitamin _ toxicity has been associated with inhibition of vitamin k absorption

vitamin A

37

two metabolites of Vitamin _ have anti- vitamin k activity

vitamin E