Week 11 Flashcards
(80 cards)
liver function
- bile production
- clearing meds
- metabolism
- protein production
- breakdown toxins
- clotting factors
loss of bile production leads to
jaundice
loss of med clearance leads to
drug toxicity
loss of clotting factors leads to
coagulopathy
loss of toxin breakdown leads to
encephalopathy
loss of protein production leads to
low albumin > edema / ascites
loss of metabolism leads to
hypoglycemia, lethargy, cachexia
hepatitis
liver injury due to inflammation
what are acute hepatitis
hepatitis A / E
what are chronic hepatitis
hepatitis B / C
what leads to increased risk of liver cirrhosis / cancer
hepatitis B / C
what are the sources of hepatitis A / E
contaminated food & water, acute illness
what are the sources of hepatitis B / C
blood products / bodily fluids
those infected with acute hepatitis B present with __
lethargy, body-aches, fever, jaundice and dark tea-
colored urine
what is a rare complication of hepatitis A / E
liver failure; transplant is the only life saving option
risk of liver cancer increased in
- males > 40 yrs, females > 50 yrs
- liver cirrhosis
- family history
- high level of hep B
- alcohol, smoking, obesity
what does lipogenesis result in
- dyslipidemia
- insulin resistance
- obesity
- metabolic syndrome
- Type 2 diabetes
what does inflammation result in
- lipid peroxidation
- mitochondrial dysfunction
- oxidative stress
- apoptosis
- pro-inflammatory cytokine activation
what does fibrosis result in
- advanced cell damage
- scarring
what are the 3 stages involved in fatty liver disease
lipogenesis, inflammation, fibrosis
what gene is associated with autoimmune hepatitis
human leukocyte antigen
gallbladder diseases
cholelithiasis, cholecystitis, biliary colic, choledocholithiasis, cholangitis
cholelithiasis
gallstones in gallbladder
cholecystitis
GB & cystic duct inflammation
