Week 8

Question 1

5 antibody classes

Answer 1

Ig M, A, D, E, G

Question 2

secondary immune response is characterized by __

Answer 2

rapid increase in IgG and remains elevated after second exposure

Question 3

major cell type in synovial fluid

Answer 3

neutrophils

Question 4

major cell type in pannus

Answer 4

T lymphocyte & macrophages

Question 5

minor cell type in pannus

Answer 5

fibroblast, plasma cells, endothelium, dendritic cells

Question 6

primary site of rheumatoid arthritis is __

Answer 6

synovium

Question 7

primary site of spondyloarthropathies is __

Answer 7

enthesis

Question 8

spondyloarthropathies process

Answer 8

mechanical injury > vasodilation > entheseal inflammation > new bone formation

Question 9

gout involves the deposition of __

Answer 9

mono sodium urate crystals

Question 10

MSU crystals activate __ pathway

Answer 10

inflammasome

Question 11

osteoarthritis is caused by __

Answer 11

aging, obesity, lifestyle choices

Question 12

what is the lead up to osteoarthritis

Answer 12

chondrosenescence

Question 13

articular pain symptoms

Answer 13

• over joint line
• global decrease in ROM
• pain at rest

Question 14

periarticular symptoms

Answer 14

• away from joint line
• decreased ROM in 1 plane
• pain upon initiating movement

Question 15

how to differentiate mechanical from inflammatory pain

Answer 15

mechanical has no morning stiffness & night pain; only gets worse with activity

Question 16

early stiffness in inflammatory arthritis is caused by __

Answer 16

IL-6

Question 17

monoarticular

Answer 17

1

Question 18

oligoarticular

Answer 18

2 - 4

Question 19

polyarticular

Answer 19

> 4

Question 20

ankylosing spondylitis affects __

Answer 20

spine, SI joint, hip, shoulder

Question 21

rheumatoid arthritis affects __

Answer 21

proximal joint of digits, symmetric, TMJ & C-spine involved

Question 22

reiter’s syndrome affects __

Answer 22

lower extremity, lumbosacral spine, SI joints, asymmetric

Question 23

psoriatic arthritis affects __

Answer 23

distal hands & feet, lumbosacral spine, SI joint, asymmetric

Question 24

osteoarthritis affects ___

Answer 24

neck, lumbosacral spine, hip, knee, 1st MTP of foot, DIP, PIP, 1st CMC of hand

Question 25

what is rheumatoid arthritis

Answer 25

autoimmune disease where joints attacked leading to chronic swelling & bone destruction

Question 26

psoriatic arthritis clinical features

Answer 26

- dactylitis - pencil in cup deformity - Achilles tendinitis - hairline psoriasis - DIPJ synovitis, onycholysis

Question 27

Arthritis mutilans in psoriatic arthritis are ___

Answer 27

telescoped digits

Question 28

ankylosing spondylitis clinical features

Answer 28

question mark posture, hyperextended neck, kyphotic, loss of lumbar lordosis, bamboo spine (used SI joints)

Question 29

stages of gout

Answer 29

asymptomatic hyperuricaemia > acute intermittent gout > chronic tophaceous gout

Question 30

x-ray images indicating gout

Answer 30

rat bite at edges, hydroxyapatite crystals leading to milwaukee shoulder & calcific tendinitis

Question 31

between RA, PsA, Gout, OA, which are inflammatory / mechanical arthritis

Answer 31

inflammatory = RA, PsA, Gout mechanical = OA

Question 32

most patients with OA will have __ knees

Answer 32

genu varus / bow legged

Question 33

patients with secondary OA will have __ knees

Answer 33

valgus

Question 34

arachidonic acid oxidation leads to __

Answer 34

eicosanoids

Question 35

eicosanoids are synthesized as needed when ___

Answer 35

activated by trauma or cytokines which activate phospholipase A2

Question 36

prostanoids include

Answer 36

prostaglandins, prostacyclin, thromboxane

Question 37

thromboxane A2 is used for __

Answer 37

platelet aggregation

Question 38

prostacyclin is used for __

Answer 38

vasodilation & inhibit platelet aggregation

Question 39

prostaglandins used for __

Answer 39

gastroprotection inflammation, pain, fever

Question 40

PGG2 converted to PGH2 by __

Answer 40

peroxidase

Question 41

DMARDs

Answer 41

disease modifying anti-rheumatic drugs for RA

Question 42

types of DMARDs

Answer 42

conventional synthetic, biological, targeted synthetic

Question 43

tofacitinib

Answer 43

janus kinase inhibitor for RA