Week 3 Flashcards
Hematocrit HCT
F = 0.37 - 0.48 (%)
M = 0.4 - 0.52 (%)
RBC count
4.5 - 5 Million per ul
Platelet count
150,000 - 300,000 per ul
WBC count
4000 - 11,000 per ul
Neutrophil G count
40 - 70%
4000 per ul
Eosinophil G count
0 - 6%
200 per ul
Basophil G count
0 - 2%
50 per ul
Lymphocyte count
20 - 50%
2000 per ul
Monocyte count
4 - 8%
500 per ul
2 Types of Hematopoiesis
Constitutive & Stress
HSC surface markers
C-Kit (Stem cell factor receptor)
CD34 (Adhesion Molecule)
Hematopoiesis steps
Embryonic SC - LTHSC - STHSC - MPP - CLP/CMP
Cytokine definition
Glycoproteins that effect cellular functions
e.g: Erythropoietin
How long does Erythropoiesis take?
7 - 10 Days
Steps of Erythropoiesis
… - CMP - MEP - Proerythroblast - Basophil EB - Polychromatophil EB - Orthochromatic EB - Reticulocyte - Erythrocyte
What regulates Erythropoiesis and where is it produced
Erythropoietin (EPO)
—-> Kidney Cortex
What does Hypoxia inducible factor HIF do?
Increases transcription of the Erythropoietin gene
3 Elements needed for erythropoiesis
Iron
Vitamin B12
Folic Acid
What happens when Iron is deficient?
RBCs small and pale
(Haemoglobin)
What happens when B12 and Folic acid are deficient?
RBCs Larger, Nucleus present, lower number.
(DNA)
Blood type H Gene
Fucosyl-transferase
Blood type A Antigen
N-acetyl-galactosamine (GalNAc)
Blood type B Antigen
Galactose
Blood types O, A, B, AB
O: H
A: H A
B: H B
AB: H A B
