Wk3 Pancreas Gallbladder and biliary tract pathology Flashcards Preview

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Flashcards in Wk3 Pancreas Gallbladder and biliary tract pathology Deck (33):
1

autodigestion of the pancreas by innaproppriately released activated pancreatic enzymes

acute pancreatitis

2

Main idea of acute panceatitis?

acinar cell injury

3

irreversible acinar tissue loss/damage by remodeling and fibrosis

chronic pancreatitis

4

IgG4 plasma cells

mimics pancreatic CA

Type I autoimmune pancreatitis

5

storiform fibrosus

sarcoid-like

IgG4 related disease

6

results from acute pancreatitis or trauma

lacks epithelial lining

contains pancreatic fluid secretions

Pseudocyst

7

benign

glycogen rich cuboidal cells

clear, thin, straw colored fluid

Serous cystadenoma

8

benign or malignant

large multi-loculated cysts

mucin filled

middle aged women

Mucinous cystic neoplasms

9

"ovarian" type stroma

Mucinous cystic neoplasm

10

mucinous neoplasm involving duct

precursor to pancreatic adenocarcinoma

head of the pancreas

Intraductal papillary mucinous neoplasm

11

Most common pancreatic neoplasm

pancreatic exocrine carcinoma

12

Most common location of pancreatic carcinoma:

head of the pancreas

13

Painless jaundice Ddx?

pancreatic carcinoma

extrahepatic cholangiocarcinoma

gallbladder carcinoma

14

Describe Whipple procedure:

removes head of pancreas, duodenum, common bile duct, gallbladder, antrum, and pylorus.

reconnects hepatic duct to jejunum, body/tail of pancreas, and body of stomach

15

Most common location for pancreatic neuroendocrine tumors?

body or tail

16

Big difference grossly between pancreatic carcinoma and neuroendocrine?

neuroendocrine are usually well circumscribed

17

Why are functioning NE tumors usually smaller than non-functioning?

because their "function" is causing sx that lead to a search for their cause

18

Majority of gallstones:

Cholesterol

19

10% of gallstones:

pigmented

20

Stones mostly comprised of bilirubin + Ca salts

pigmented

21

Radioopaque type of gallstone?

pigmented

22

imaging of choice for gallstone Dx?

ultrasound

23

Population with higher risk of pigmented stones?

east asian

24

Pigmented stones in a young person; think?

hemolytic disease process

biliary tract infx

**increased unconjugated bilirubin

25

most common cause of extrahepatic biliary obstruction?

choledocholithiasis--stones in the common bile duct

26

Stone size most likely to cause sx?

small

27

edematous gallbladder with abscess, necrosis and neutrophilic infiltrate?

acute cholecystitis

28

gallbladder with varying degrees of lymphocytic infiltration and and fibrosis?

chronic cholecytitis

29

"porcelain gallbladder"

chronic cholecystitis

-dystrophic calcification of the gallbladder wall

30

hypertrophy of the gallbladder muscular wall?

Adenomyoma

31

Two big associations with carcinoma of the gallbladder?

age over 50

cholelithiasis (95%)

32

Gallbladder carcinoma is_____?

rare!

..and typically silent

33

Dx requirement for cholangiocarcinoma?

tissue biospy/cytology