Flashcards in Wk3 Pancreas Gallbladder and biliary tract pathology Deck (33):
autodigestion of the pancreas by innaproppriately released activated pancreatic enzymes
Main idea of acute panceatitis?
acinar cell injury
irreversible acinar tissue loss/damage by remodeling and fibrosis
IgG4 plasma cells
mimics pancreatic CA
Type I autoimmune pancreatitis
IgG4 related disease
results from acute pancreatitis or trauma
lacks epithelial lining
contains pancreatic fluid secretions
glycogen rich cuboidal cells
clear, thin, straw colored fluid
benign or malignant
large multi-loculated cysts
middle aged women
Mucinous cystic neoplasms
"ovarian" type stroma
Mucinous cystic neoplasm
mucinous neoplasm involving duct
precursor to pancreatic adenocarcinoma
head of the pancreas
Intraductal papillary mucinous neoplasm
Most common pancreatic neoplasm
pancreatic exocrine carcinoma
Most common location of pancreatic carcinoma:
head of the pancreas
Painless jaundice Ddx?
Describe Whipple procedure:
removes head of pancreas, duodenum, common bile duct, gallbladder, antrum, and pylorus.
reconnects hepatic duct to jejunum, body/tail of pancreas, and body of stomach
Most common location for pancreatic neuroendocrine tumors?
body or tail
Big difference grossly between pancreatic carcinoma and neuroendocrine?
neuroendocrine are usually well circumscribed
Why are functioning NE tumors usually smaller than non-functioning?
because their "function" is causing sx that lead to a search for their cause
Majority of gallstones:
10% of gallstones:
Stones mostly comprised of bilirubin + Ca salts
Radioopaque type of gallstone?
imaging of choice for gallstone Dx?
Population with higher risk of pigmented stones?
Pigmented stones in a young person; think?
hemolytic disease process
biliary tract infx
**increased unconjugated bilirubin
most common cause of extrahepatic biliary obstruction?
choledocholithiasis--stones in the common bile duct
Stone size most likely to cause sx?
edematous gallbladder with abscess, necrosis and neutrophilic infiltrate?
gallbladder with varying degrees of lymphocytic infiltration and and fibrosis?
-dystrophic calcification of the gallbladder wall
hypertrophy of the gallbladder muscular wall?
Two big associations with carcinoma of the gallbladder?
age over 50
Gallbladder carcinoma is_____?
..and typically silent