012015 gut immunity Flashcards Preview

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Flashcards in 012015 gut immunity Deck (14):
1

host defense barriers

--immediate (existing physical and chemical barriers)
--early (existing innate immune cells and mediators)
--late (actiavtion of appropriate adaptive immune cells and mediators)

2

cell associated pattern recognition receptors

TLRs
NLRs (in cytoplasm)
mannose receptors

3

soluble pattern recognition receptors

C reactive protein
mannose binding lectin
complement - C3
IgM

these are all located in the plasma

4

fxn of TLRs

activate genes necessary for defense against bacterial (TNF, IL1, IL6), viral (IFNalpha/beta), or fungal organism

5

innate immune response for bacteria

neutrophils
DCs
activated macrophage
cytokines (IL12, TNF, IL1, IL6, TGFbeta)

6

what leads to differentiation to a Th17 cell?

TGFbeta, IL6, IL23

7

review of cytokines

see slide 26

8

classical pathway for complement involves

IgM coating bacteria

9

lectin pathway for complement involves

mannose binding lectin coating bacteria

10

C3b plays what role

opsonization and phagocytosis

11

C5a and C3a serve what role

inflam

12

recognition receptors for intestinal viruses

TLRs
NLRs
antibody (IgM)

13

anti viral innate immune response

epithelial cells secrete IFNa/b to boost antiviral immunity in neighboring cells

DC engulfs and takes to Peyer's patch. causes native T cell to become CD8 CTL. also causes naitve T cells to become Th1 cells, which activate macrophages and naive B cells through IFNgamma.

NK cell secretes IFNgamma

14

innate immuneo response against parasites

granulocytes are important (eosinophil, basophil, mast cells). granulocytes are activated by Ag-bound IgE binding cell surface FceRI receptor--this depends on previous exposure to an antigen

parasites are too big to be engulfed!