Flashcards in 012115 mucosal immunity Deck (21):
fxn of M cell
to sample lumenal contents and deliver to Peyer's patch
what makes DCs and T cells tolerogenic in mucosa?
retinoic acid, TSLP, TGFbeta
(they enhance MadCAM, CCL25, CCR9)
gut homing signals
what drives the class switching in plasma cells to IgA?
class switching occurs through 2 mechanisms in gut-what are they?
retinoic acid and TGFbeta have what effect on T cells?
skews T cells to Th17 and regulatory T cells
antigen vs immunogen
antigen-molecule bind to antibody or T cells
immunogen-moledulce induces immune response
molecule that induces immune unresponsiveness to subsequent doses
what makes something an immunogen?
route-subcutaneous has increased immunogenicity compared to intragastric
interaction with MHC complex-effective
non responsiveness to food and microbiota is mediated by
regulatory T cells
how do mucosal DCs regulate tolerance in the gut?
gut DCs take up antigens from gut (food or microbiota), travel to mesenteric lymph node, and present Ag to naive T cells
they produce retinoic acid and TGFbeta, driving differentiation of CD4 naive T cells to become regulatory T cells
what three things predispose you to autoimmunity?
uncontrolled immune response
excessive or aberrant immune responses following challenge w antigen
what genes is celiac dis associated w
what type of hypersensitivity is celiac dis?
type IV (Th1 T cells and inflam response)
what antibodies do you see in celiac dis?
loss of tolerance to microbiota (due to mutations in Nod pattern recognition receptor genes, or mutations in autophagy genes)
IBD is associated with what HLA types
what type of hypersensitivity is IBD?
type IV (Crohn's is Th1, UC is Th2)
NO loss of tolerance, NOT autoimmunity