012115 mucosal immunity Flashcards Preview

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Flashcards in 012115 mucosal immunity Deck (21):
1

fxn of M cell

to sample lumenal contents and deliver to Peyer's patch

2

what makes DCs and T cells tolerogenic in mucosa?

retinoic acid, TSLP, TGFbeta
(they enhance MadCAM, CCL25, CCR9)

3

gut homing signals

alpha4beta7
CCR9
MadCAM
CCL25

4

what drives the class switching in plasma cells to IgA?

TGFbeta

5

class switching occurs through 2 mechanisms in gut-what are they?

T dependent
T independent

6

retinoic acid and TGFbeta have what effect on T cells?

skews T cells to Th17 and regulatory T cells

7

antigen vs immunogen

antigen-molecule bind to antibody or T cells
immunogen-moledulce induces immune response

8

toleragen

molecule that induces immune unresponsiveness to subsequent doses

9

what makes something an immunogen?

size-large
dose-intermediate
route-subcutaneous has increased immunogenicity compared to intragastric

composition-complex
adjuvant-bacteria
interaction with MHC complex-effective

10

non responsiveness to food and microbiota is mediated by

regulatory T cells

11

how do mucosal DCs regulate tolerance in the gut?

gut DCs take up antigens from gut (food or microbiota), travel to mesenteric lymph node, and present Ag to naive T cells

they produce retinoic acid and TGFbeta, driving differentiation of CD4 naive T cells to become regulatory T cells

12

what three things predispose you to autoimmunity?

genetic suscpetibility
environmental trigger
uncontrolled immune response

13

hypersensitivity

excessive or aberrant immune responses following challenge w antigen

14

what genes is celiac dis associated w

HLA-DQ2, HLA-DQ8

15

what type of hypersensitivity is celiac dis?

type IV (Th1 T cells and inflam response)

16

what antibodies do you see in celiac dis?

anti gliadin
anti tTG
anti endomysium

17

IBD

loss of tolerance to microbiota (due to mutations in Nod pattern recognition receptor genes, or mutations in autophagy genes)

18

IBD is associated with what HLA types

HLA-DR, HLA-B27

19

what type of hypersensitivity is IBD?

type IV (Crohn's is Th1, UC is Th2)

20

food allergy

NO loss of tolerance, NOT autoimmunity

21

what type of hypersensitivity is a food allergy?

type I