11. Antiepileptics used in absence seizures. “Broad spectrum” antiepileptic drugs. Drugs used for treatment of status epilepticus Flashcards Preview

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Flashcards in 11. Antiepileptics used in absence seizures. “Broad spectrum” antiepileptic drugs. Drugs used for treatment of status epilepticus Deck (11)
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1

For absence seizures Treatment of petit mal seizures

Clonazepam
Clobazam
Ethosuximide

2

Broad spectrum antiepileptic drugs

Valproate
Lamotrigine
Topiramate

3

Drugs used for treatment of status epilepticus

Fast acting medication followed by a slower-acting medication

drugs in acute case ...
Diazepam first than ...
Phenytoin
phenobarbital

In highly resistant cases of status epilepticus when it remains even with anti-epileptic drugs than give -general anesthesia

4

Clonazepam

benzodiazepine
First line drug in absence seizure and Lennox-Gastaut syndrome

5

Clobazam

benzodiazepine derivative
1st line for severe anxiety

6

Ethosuximide

Inhibiting T-type Ca++ channels

7

Valproate

First line
Inhibits voltage-gated sodium channels, Inhibits T-type calcium channels, Enhances GABA transmission
used in bipolar and migraine as prophylaxis
AE: teratogenic, hematological and neurological abnormalities

8

Lamotrigine

Inhibits voltage-gated sodium channels
also for Bipolar

9

Topiramate

Inhibits AMPA receptor Inhibits voltage-gated Na+ channels, stimulates GABAA receptors
also for migraine as prophylaxis
AE: Nephrolithiasis, Teratogenic

10

absence seizures

brief abrupt self limiting loss of consciousness
usually in children
A.K.A petit mal seizures

11

status epilepticus

a single epileptic seizure lasting more than five minutes or two or more seizures within a five-minute period without the person returning to normal between them