9. norepinephrine and serotonin receptor antagonist antidepressants. Agomelatine. Tianeptine. Agents used for treatment of manic phase of bipolar disorders Flashcards Preview

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Flashcards in 9. norepinephrine and serotonin receptor antagonist antidepressants. Agomelatine. Tianeptine. Agents used for treatment of manic phase of bipolar disorders Deck (16)
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1

Norepinephrine and serotonin receptor antagonist antidepressants

that are selective Serotonin reuptake inhibitors that have direct antagonistic effect on restorers and and 5-HT2(3) antagonist and NE reuptake inhibitor

that are NE reuptake inhibitors & α2 and 5-HT2, (3) antagonist

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Serotonin reuptake inhibitors & 5-HT2A antagonists

AE: hepatotoxic, very sedative
Moderate α1 receptor antagonism

drugs ...
Trazodone
Nefazodone

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Serotonin reuptake inhibitors & 5-HT1A partial agonist

Vilazodone

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Serotonin reuptake inhibitors & 5-HT3A , 5-HT7 antagonist, 5-HT1A,B partial agonis

Vortioxetine

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NE reuptake inhibitors α2 and 5-HT2, (3) antagonist

Mirtazapine
Mianserine

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Agomelatine

Melatonin (MT1 MT2) agonist
5-HT2C inhibition
recovery of circadian rythem
incraes sexual function & sleep

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Tianeptine

Enhances of 5-HT reuptake

8

treatment of manic phase of bipolar disorders

Lithium carbonate
Anticonvulsant agents
Ca++ channel blockers
some Antipsychotics

9

Trazodone

Serotonin reuptake inhibitors & 5-HT2A antagonists
used for insomnia as well

10

Mirtazapine

NE reuptake inhibitors & α2 and 5-HT2, (3) antagonist
highly sedative

11

Anticonvulsant agents

Carbamazepine
Valproate
Clonazepam

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Ca++ channel blockers

Verapamil

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in what situation using Antipsychotics in bipolar

acute phase & mood stabilizer

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Antipsychotics for acute phase

Haloperidol
Clozapine

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Antipsychotics for mood stabilizer

Olanzapine
Quetiapine
Risperidone
Aripiprazole
Ziprasidone

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Lithium carbonate

used for Acute & prophylactic managing of bipolar patients
Low TI
half-life ~20hr
complete GI absorption
No metabolism