7. Tricyclic, tetracyclic and unicyclic antidepressants. MAO-inhibitors Flashcards Preview

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Flashcards in 7. Tricyclic, tetracyclic and unicyclic antidepressants. MAO-inhibitors Deck (18)
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1

Tricyclic antidepressants

inhibits NE and 5-HT reuptake
secondary choice
Blocking H1 ,α1, M, 5-HT2
narrow TI

drugs ...
Amitriptyline
Imipramine
Trimipramine
Desipramine
Clomipramine

2

tetracyclic antidepressants

Maprotiline
Amoxapine
Mirtazapine

3

unicyclic antidepressants

Bupropion

4

Amitriptyline

5-HT = NE reuptake
prevent migraine and neuropathic pain

5

Imipramine

5-HT > NE reuptake
for bed-wetting in children >6 replaced by desmopressin

AE: orthostatic hypotension

6

Trimipramine

AE: Very marked sedation

7

Desipramine

Tricyclic antidepressants
NE > 5-HT reuptake

8

Maprotiline & Amoxapine

tetracyclic antidepressants
NE > 5-HT reuptake

9

Mirtazapine

no sexual side effect

10

Bupropion

no sexual side effects

AE: has CNS activating properties
weak DA and NE reuptake inhibitor
smoking cessation

11

MAO-inhibitors

last line of action in antidepressant

types ...
Non-selective irreversible
selective reversible
selective irreversible

12

Non-selective irreversible MAO-inhibitors

for severe depression
AE: cheese effect

drugs ...
Phenelzine
Tranylcypromine

13

selective reversible MAO-inhibitors

Moclobemide

14

selective irreversible MAO-inhibitors

Selegiline

15

Selegiline

used for parkinson's disease & depression
MAO B inhibitor selective ireversible
minimal chees effect

16

cheese effect

acute attack of hypertension
occur in a person taking a MAOI drug & eats cheese /drinks red wine
cussed by the interaction of the MAOI with tyramine from the food
especially by irreversible MAOI

17

Moclobemide

depression
selective reversible MAO A inhibitor

18

treatment of major depression

SSRI + MAO inhibitor