12. Drugs used for treatment of neurodegenerative disorders. Nootropic drugs Flashcards Preview

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Flashcards in 12. Drugs used for treatment of neurodegenerative disorders. Nootropic drugs Deck (42)
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1

neurodegenerative disorders

Parkinson’s disease
Alzheimer’s disease
multiple sclerosis
amyotrophic lateral sclerosis (ALS)
Wilson’s disease
dementias
Huntington disease

2

drugs for Parkinson’s disease

Dopamine precursors
Dopamine receptor agonists
Dopamine turnover enhancer
MAO inhibitors
COMT inhibitors
Antimuscarinic agents

3

drugs for Alzheimer’s disease

Centrally acting acetylcholinesterase inhibitors
NMDA receptor antagonists
Antioxidants

4

drugs for multiple sclerosis

Interferon β1a and β1b

5

drugs for amyotrophic lateral sclerosis (ALS)

Riluzole

6

drugs for Wilson’s disease

Penicillamine

7

drugs for dementias

Nootropic drugs
Antioxidants
Calcium antagonists
NSAIDs
Estrogens

8

drugs for Huntington disease

Tetrabenazine

9

Dopamine precursors

Levodopa

10

Levodopa

Good Gi absorption & goes threw BBB
AE: GI + cardiovascular, in CNS: mood, hallucinations and movement.

11

Carbidopa

Given with levodopa
peripheral DOPA decarboxylase inhibitor

12

Pyridoxine

Vit. B6
increases decarboxylase activity

13

MAO inhibitors used in Parkinson

Selegiline
Rasagiline

14

Selegiline

used in Parkinson & depression & Alzheimer’s disease
ireversible MAO-B

15

Rasagiline

used in Parkinson
irreversible and selective inhibitor of brain MAO-B
rasagiline is not metabolized to an amphetamine-like substance

16

COMT inhibitors

selectively and reversibly inhibit COMT
inhibits consumption of levodopa

drugs...
Entacapone
Tolcapone

17

Dopamine receptor agonist

long duration of action
good for patients with fluctuating symptoms

types ...
Ergot & Non-ergot derivative

18

Non-ergot derivative

Ropinirole
Pramipexole
Rotigotine
Apomorphine

19

Ergot derivative

has the potential to cause pulmonary and retroperitoneal fibrosis

druges
Bromocriptine
Cabergoline
Pergolid

20

Apomorphine

used in Parkinson
for acute management of the hypomobility “off” phenomenon
given IV

21

Ropinirole

used in Parkinson
given oral

22

Pramipexole & Rotigotine

used in Parkinson
patch

23

Bromocriptine

used in Parkinson
Ergot derivative
has the potential to cause pulmonary and retroperitoneal fibrosis

24

Amantadine

antiviral drug (against influenza)
increasing dopamine release, decreased dopamine uptake, blocking cholinergic receptors and inhibiting the NMDA receptors

25

Antimuscarinic agents

Benztropine
Orphenadrine
Procyclidine
Biperide

26

Dopamine turnover enhancer

Amantadine

27

Biperiden

used in Parkinson & used for nicotine and organophosphate intoxication (by injection)

28

Benztropine

works on M1 receptor in the CNS

29

Centrally acting acetylcholinesterase inhibitors

used in Alzheimer’s disease
in cases of mild to moderate

drugs...
Donepezil
Tacrine
Rivastigmine
Galantamine

30

Galantamine

used in Alzheimer’s disease
may also augment the action of acetylcholine at nicotinic receptors in the CNS
Lipid soluble