4. Non benzodiazepine anxiolytics and non-benzodiazepine hypnotics Flashcards Preview

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Flashcards in 4. Non benzodiazepine anxiolytics and non-benzodiazepine hypnotics Deck (14)
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1

Cyclopyrrolone or imidazopyridine derivatives

minor effect on sleep patterns
less tolerance and dependence than Benzodiazepines

drugs...
Zaleplon
Zolpidem
Eszopiclone

2

Zaleplon & Zolpidem

selectively acting on BDZ1

3

Non-GABAergic hypnotics

Ramelteon

4

Non-GABAergic anxiolytics

Buspirone
Reuptake inhibitors

5

Barbiturates

act on GABA.A
disadvantages tolerance and physical dependence withdrawal symptoms
induce full surgical anesthesia
AE: low margin of safety !no antidote for barbiturates

types ...
Long acting
Medium and short-acting
Ultra-short acting

6

Long acting Barbiturates

Phenobarbital

7

Medium and short-acting Barbiturates

Cyclobarbital
Amobarbital

8

Ultra-short acting Barbiturates

IV anesthetics
20 min duration of action
mainly for induction

drugs ...
Thiopental
Methohexital

9

Phenobarbital

antiepileptic

10

Cyclobarbital & Amobarbital

short-acting Barbiturates
Hypnotic

11

Ramelteon

Non-GABAergic hypnotics
Selective MT1 and MT2 (melatonin receptors)
for falling asleep
no rebound insomnia

12

Buspirone

Non-GABAergic anxiolytics (5-HT1a)
partial agonist at brain 5-HT1A receptors + some affinity for D2 and 5-HT2A receptors

13

Reuptake inhibitors

Non-GABAergic anxiolytics
for chronic panic attacks
1st line in chronic anxiet
used in depression as well

type
SSRI

14

hypnotics non BZN GABAergic

Cyclopyrrolone or imidazopyridine derivatives
Barbiturates

elderly patients more sensitive to side effect of this