Adaptive Immune System 1

Question 1

B cells express antigens like?

Answer 1

CD19

Question 2

Cells express antigens such as?

Answer 2

CD3 CD4 CD8

Question 3

T helper cell division?

Answer 3

Th1
Th2
Th17
Treg

Question 4

B cells develop in?

Answer 4

Stromal cells in bone marrow

Question 5

Average life expectancy of naive B cell?

Answer 5

5 days

Question 6

In adults what happens to thymus?

Answer 6

Some residual corticomedullary tissue with thymocytes

New T cells generated in extrathymic sites

Long lived peripheral T cell pool

Question 7

Which cells die or remain?

Answer 7

Negative and positive selection

Question 8

What are common stages of b and T cell development?

Answer 8

1. Generation of antigen receptor
2. Refinement of the antigen receptor repertoire (positive and negative selection)
3. Stimulation by foreign antigen

Question 9

Thymus dependent antigen?

Answer 9

Dependent upon t helper cells to induce antibody production e.g protein

Most igM

Question 10

Thymus independent antigens example?

Answer 10

Polysaccharides and lipids

Question 11

B cells are activated by?

Answer 11

Direct BCR cross linking

Question 12

B cells often require a second activation signalling through?

Answer 12

Toll like receptor engagement

Question 13

Signalling complex in membrane for B cell is?

Answer 13

Ig alpha and igbeta

Question 14

Signalling complex for T cell membrane?

Answer 14

Cd3

Question 15

B and T cell interaction?

Answer 15

Signal 1 through antigen receptor

Signal 2 co stimulation

Question 16

CD80/CD86 on B cell bind to?

Answer 16

CD28 on T cell providing signal 2 to T cell

Question 17

T cell activation leads to up regulation of what?

Answer 17

CD40L which binds to Cd40 providing signal 2 to B cell

Cytokines production by activated T cell can activate B cell signal 3