Cancer Immunology And Immunotherapy Flashcards
How do T cells detect cancerous cells?
Tumour associated, higher levels in tumour cells and tumour specific genes
What is associated with liver cancer?
Alpha fetoprotein, expressed in a few other cells
MAGE-A antigens are found in?
Non-small cell lung cancer, bladder and esophageal cancer
What is the antigen for prostate cancer?
Porstatic acid phosphatase
BRCA 1 and 2 are found in how many women?
1 in 500
BRCA1 and 2 increase risk of varian and breast cancer by?
Ovarian cancer- 30-45x
Breast cancer- 2-5 risk
BRCA1 and 2 affect?
Regulatory RAD51- DNA repair protein, repairs double strand breaks
Sipuleucel T is what?
A vaccine composed of patient immune cells that were expanded by stimulation with PAP
Tumours can subdue immunity by?
- Cytokines downregulating inflammation e.g IL10
- Reducing tumour MHC expression
- Reducing T cell immunity at immune check points by expressing inhibitory ligands
What happens at immunological synapse?
T cells change configuration through micro tubules, majority of receptors moved towards the immunological synapse.
Cd43 mediates repulsion so excluded
Costimualation of T cells?
CD80/86 with CD 28
ICAM1- LFA 1
Anti checkpoint?
Programmes death L 1 PD-L1 on APC with PD1- on T cells induces dephosphorylation
PD1- PD-L1 drug?
Dostarlimab
What is an anti- inflammatory cytokine?
IL10
Life time risk of average women with cancer due to BRCA1 and BRCA2 is?
12.5
