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VMS2007 Pathology of the Endocrine, and Neurological Systems and Organs of Special Senses > Infection and Inflammation of the CNS > Flashcards

Infection and Inflammation of the CNS Flashcards

1
Q

Defence mechanisms in the brain (4)

A
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2
Q

What are the different routes of infection + examples? (4)

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3
Q

General features of lesions and the nature of the infecting organism (4)

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4
Q

Suppurative inflammation - bacterial? fungal/algal/protozoan/helminth? viral? non-infectious agents?

A

Bacterial = Listeria, embolic diseases, septicaemias

Fungal/algal/protozoan/helminth = Aspergillus, Amebae, Prototheca, Encephalitozoon cuniculi

Viral = arbovirus

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5
Q

Eosinophilic inflammation - bacterial? fungal/algal/protozoan/helminth? viral? non-infectious agents?

A

Fungal/algal/protozoan/helminth = Helminths (coenurus, cysticercus)

Non-infectious = allergy?

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6
Q

Suppurative-pyogranulomatous inflammation - bacterial? fungal/algal/protozoan/helminth? viral? non-infectious agents?

A

Fungal/algal/protozoan/helminth = Toxoplasma gondii, Neospora caninum, Cryptoccocus neoformans, Sarcocystis neurona

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7
Q

Non-suppurative inflammation (lymphocytes + plasma cells) bacterial? fungal/algal/protozoan/helminth? viral? non-infectious agents?

A

Viral = Rabies, Aujeszky, Distemper, EEE, VEE, JEE, EHV*, West Nile, Borna

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8
Q

Non-suppurative/granulomatous inflammation - bacterial? fungal/algal/protozoan/helminth? viral? non-infectious agents?

A

Bacterial = mycobacteria

Viral = Visna-maedi, CAEV, EIAV, FIP

Non-infectious agents = GME = granulomatous meningoencephalitis, NME = necrotising meningoencephalitis

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9
Q

Grey matter inflammation (polio) - bacterial? fungal/algal/protozoan/helminth? viral? non-infectious agents?

A

Viral = Rabies, Aujeszky, EEE, VEE, JEE, EHV*, West Nile, Borna

Non-infectious = NME = necrotising meningoencephalitis

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10
Q

White matter inflammation (leuko) - bacterial? fungal/algal/protozoan/helminth? viral? non-infectious agents?

A

Viral = Distemper, Border disease, Visna-Maedi

Non-infectious = GME = granulomatous meningoencephalitis

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11
Q

Vasculitis - bacterial? fungal/algal/protozoan/helminth? viral? non-infectious agents?

A

Bacterial = TME = thrombotic meningoencephalitis

Viral = FIP, herpesviruses, CSF, ASF, MCF

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12
Q

What do bacterial infections involve and the common patterns associated with inflammation (7)

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13
Q

What is meningitis? species, bacteria, portal of entry, clinical signs (13)

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14
Q
A

Diffuse suppurative meningitis - pig

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15
Q
A

Suppurative meningitis

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16
Q

What are cerebral abscesses? (2)

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17
Q

Cerebral abscesses - haematogenous location (2)

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18
Q

Cerebral abscesses - direct invasion locations (5)

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19
Q

What are the histopathological features of cerebral abscesses? (6)

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20
Q

Septic embolism and thromboembolism to the brain - bacterial agents and outcomes (5)

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21
Q

What is thrombotic meningoencephalitis (TME)? (6)

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22
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23
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24
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25
Q

What is listeriosis - areas affected, route of infection (7)

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26
Q

Where are the areas of lesions of listeriosis?

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27
Q

Listeria - histo

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28
Q

Aetiology of granulomatous/pyogranulomatous encephalitis (7)

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29
Q
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30
Q

What do CNS viral infections involve? (8)

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31
Q

How is rabies spread?

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32
Q

What are the histopathological features of viral infections? (7)

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33
Q

What are the different equine viral diseases? (4)

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34
Q

Canine distemper virus - CNS features (4)

A
  • Non-suppurative encephalitis, mostly of WM
  • Demyelination of WM
  • Secondary gliosis
  • Inclusion bodies
35
Q

Canine distemper - systemic disease features (7)

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36
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37
Q

What do protozoan infections involve? (6)

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38
Q
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39
Q

What do fungal and algal diseases involve? (6)

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40
Q
A

GID = coenurus

41
Q

What is granulomatous meningoencephalomyelitis (GME)? (4)

A

Non-infectious encephalitides (auto-immune disease)

42
Q

What is necrotising meningoencephalitis (NME)? (4)

A

Non-infectious encephalitides (auto-immune disease)

43
Q

Granulomatous menigoencephalomyelitis (GME) - gross pathology

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44
Q

Granulomatous menigoencephalomyelitis (GME) - histopathology

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VMS2007 Pathology of the Endocrine, and Neurological Systems and Organs of Special Senses (36 decks)

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