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CLS 306 > CH.5 > Flashcards

CH.5 Flashcards

1
Q

T or F: immunoglobulins are antibodies

A

T

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2
Q

where are the heavy chains located on an immunoglobulin

A

inner

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3
Q

where are the light chains located on an immunoglobulin

A

outer

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4
Q

where is the variable region on an immunoglobulin

A

top

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5
Q

where is the constant region on an immunoglobulin

A

bottom

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6
Q

does the Fc fragment bind to Ag

A

no

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7
Q

what part of the immunoglobulin plays an important part in effector functions

A

Fc fragment

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8
Q

what makes up the fab fragment

A

one light chain and 1/2 of heavy chain

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9
Q

what does papain digestion of immunoglobulin yield

A

2 fab fragments and an Fc portion

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10
Q

what does pepsin digestion of immunoglobulin yield

A

Fab 2 fragment and Fc portion in pieces

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11
Q

what makes the light chains

A

malignant plasma cells

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12
Q

what kind of chains are kappa and lambda

A

light

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13
Q

which immunoglobulin has kappa and lambda light chains

A

found in all immunoglobulin

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14
Q

what kind of heavy chain does IgG have

A

gamma

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15
Q

what kind of heavy. chain does IgM have

A

mu

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16
Q

what kind of heavy chain does IgA have

A

alpha

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17
Q

what kind of heavy chain does IgD have

A

delta

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18
Q

what kind of heavy chain does IgE have

A

epsilon

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19
Q

what kind of variation do isotope immunoglobulin have

A

H chain

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20
Q

what kind of variation do allotrope immunoglobulin have

A

constant regions

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21
Q

what kind of variation do idiotype immunoglobulin have

A

variable regions

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22
Q

where is the hinge region located

A

on heavy chain between CH1 and CH2

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23
Q

what allows flexibility and hydrophobic residues in the hinge region

A

proline

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24
Q

what are the direct functions of an Ab

A

neutralization, agglutination, and precipitation

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25
Q

what are the indirect functions of a Ab

A

inflammation, phagocytosis, and complement

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26
Q

what does the fab fragment bind to

A

Ag

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27
Q

what do phagocytic cells recognize on Ab bound to Ag

A

fc region

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28
Q

what is the most common immunoglobulin

A

IgG

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29
Q

what immunoglobulin has the longest 1/2 life

A

IgG

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30
Q

where do you find IgG

A

plasma of serum

31
Q

which immunoglobulin has the highest molecular weight

A

IgM

32
Q

which immunoglbulin can cross the placenta

A

IgG

33
Q

T or F: IgG2 can cross the placenta

A

F

34
Q

what kind of rxns does IgG cause

A

agglutination

35
Q

when do maternal IgG stop crossing placenta

A

at birth

36
Q

what increases the efficiency of phagocytosis when dealing with IgG

A

phagocytic cells have specific Fc receptors for IgG

37
Q

which immunoglobulin can enter extravascular spaces easily

A

IgG

38
Q

what kind of immunoglobulin is IgM

A

macroglbulin

39
Q

where is IgM found

A

intravascular pool

40
Q

what is the 1st immunoglobulin to respond after attack

A

IgM

41
Q

what form is IgM

A

pentamer

42
Q

what holds together the pentamer formation of IgM

A

J chains

43
Q

T or F: IgM has a short lived response but long lag phase

A

T

44
Q

when will IgM stop being synthesized

A

after Ag is gone

45
Q

does IgM have memory

A

no

46
Q

does IgG have memory

A

yes

47
Q

what kind of infection is IgM best at fighting

A

bacterial

48
Q

what is the 1st immunoglobulin to be rearranged

A

IgM

49
Q

if a lymph has a mmb IgM what does that indicate

A

immature B Cells

50
Q

where do you find IgA

A

serum

51
Q

what immunoglobulin is found in breast milk, saliva, sweat, and tears

A

IgA

52
Q

what immunoglobulin is the first line of defense on mucosal surfaces

A

IgA

53
Q

where does secretory IgA transport to

A

MALT

54
Q

where do you find IgD

A

surface of immunocompetent but unstimulated B lymphs

55
Q

what is the 2nd immunoglobulin to respond after attack

A

IgD

56
Q

if B lymphs have IgM receptors will an IgG response occur

A

no

57
Q

b lymphs with both IgM and IgD will respond to what

A

T cells

58
Q

what immunoglobulin do the lungs and the skin plasma cells produce

A

IgE

59
Q

what immunoglobulin do mast cells bind

A

IgE

60
Q

when is the light chain rearranged

A

not until the heavy chain is completed

61
Q

T or F: the heavy chain is always rearranged 1st

A

T

62
Q

which light chain is rearranged 1st

A

kappa

63
Q

after kappa what light chain is rearranged

A

VJ

64
Q

after the light chain is rearranged what does it join with

A

mu heavy chain

65
Q

what makes up the mature Kappa light chain

A

VJ segment and C region

66
Q

what is isotope switching

A

when a B cell changes what immunoglobulin is being produced

67
Q

what changes are made to constant and variable regions of the ab

A

constant region changes but variable region stays the same

68
Q

how is the constant region changed in isotope switching

A

loop is made and then deleted –> new constant region binds

69
Q

t or f: monoclonal ab are not very specific

A

F

70
Q

what are monoclonal Ab mainly. used for

A

diagnostic testing and terapeutic purposes

71
Q

where do monoclonal ab come from

A

single parent ab that has reproduced many times

72
Q

what is a hybridoma

A

monoclonal ab

73
Q

what makes up a hybridoma

A

activated B cell with myeloma cell

74
Q

why can’t hybridoma make it own DNA

A

is lacks the enzyme

CLS 306 (19 decks)

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