Ch.7

Question 1

what enhances host defense mechanisms

Answer 1

complement

Question 2

complement proteins are synthesized where

Answer 2

liver

Question 3

where are C1 components produced

Answer 3

intestinal epithelial cells

Question 4

where is factor D made

Answer 4

adipose tissue

Question 5

def? inactive precursors

Answer 5

zymogens

Question 6

T. or F: most of the complement proteins zymogens

Answer 6

T

Question 7

what is the end product of complement

Answer 7

lysis of invading cell

Question 8

what amplifies inflammatory reactors

Answer 8

complement

Question 9

does vascular permeability increase or decrease during complement

Answer 9

increase

Question 10

what kind of cells do complement recruit during inflammation

Answer 10

monocytes and neutrophils

Question 11

what are the 3 pathways for complement

Answer 11

classical, lectin, and alternative

Question 12

what activates complement in the classical pathway

Answer 12

Ag-Ab complex

Question 13

what activates complement in the alternative pathway

Answer 13

pathogen surface agent

Question 14

what activates complement in the lectin pathway

Answer 14

lectin binding to pathogen surface (carbohydrates)

Question 15

what do complement fragments act as

Answer 15

opsonins

Question 16

def? a substance that makes other cells more susceptible to phagocytosis

Answer 16

opsonin

Question 17

what is the 1st stage of complement

Answer 17

recognition unit

Question 18

what protein is involved in the recognition stage of complement

Answer 18

C1

Question 19

once C1 is fixed what are the next proteins activated

Answer 19

C4, C2, and, C3

Question 20

what proteins make up the activation unit

Answer 20

C4, C2, and C3

Question 20

what proteins make up the activation unit

Answer 20

C4, C2, and C3

Question 21

what is the most effective immunoglobulin of the classical pathway

Answer 21

IgM

Question 22

why is IgM the most efficient in the classical pathway

Answer 22

because it has multiple binding sites

Question 23

T or F: CRP, some viruses, mycoplasma, some gram – bacteria(E.coli) can also activate Classical Pathway

Answer 23

T

Question 24

what part of C1 binds the constant region of the Ab

Answer 24

C1q

Question 25

what part of C1 generate enzyme activity

Answer 25

2 C1r

Question 26

what complement protein is stabilized by Ca

Answer 26

C1

Question 27

what activates C1s

Answer 27

cleaving of thirster bond

Question 28

what ends the recognition stage of the classical pathway

Answer 28

activation of C1s

Question 29

what is the name of C5-C9

Answer 29

mmb attack complex

Question 30

what is the last unit the completes the lysis of the foreign particle

Answer 30

mmb attack complex

Question 31

what complement pathway is ab independent

Answer 31

lectin pathway

Question 32

what is the major constituent of the lectin pathway

Answer 32

mannose

Question 33

where is mannose found

Answer 33

in the cell wall of bacteria

Question 34

what complement pathway do babies use

Answer 34

lectin pathway

Question 35

what are the lectin and classical pathway the same

Answer 35

after C4 and C2 are cleaved

Question 36

what does the alternative pathway do for the other pathways

Answer 36

amplification loop for them

Question 37

T or f: the alternative pathway can be activated on its own

Answer 37

T

Question 38

what happens if you can not control complement

Answer 38

large amounts of tissue damage

Question 39

what regulates that infectious agents get destroyed and the rxn remains localized

Answer 39

plasma proteins

Question 40

what is the main step that stops complement

Answer 40

halting the accumulation of C3b