Complement System- Regulation Flashcards
1
Q
Complement activation is regulated by a series of proteins that serve to _________ cells from accidental damage
A
Protect
2
Q
What is the C1 inhibitor?
A
C1NH
3
Q
In the regulation of C3 convertase, what is the active C3 convertase?
A
C4b2b
4
Q
What does the following do:
DAF, CR1, MCP, and C4BP
A
Displace C2b from C4b2b
5
Q
What can DAF, CR1, MCP, and C4BP do to C3 convertase?
A
Inactivate it
6
Q
In the regulation of C5 convertase,
What is C4b2b3b?
A
Active C5 convertase
7
Q
In the regulation of C5 convertase,
What 2 things displace C3b?
A
CR1 and H
8
Q
What do CR1, H, and I factor do to C5 convertase?
A
Inactivate it
9
Q
In the regulation of C5 convertase, what is CD59?
A
Protectin
10
Q
In the regulation of membrane attack complex (MAC)-
What can block the formation of MAC?
A
CD59
