MHC- Last Part

Question 1

Each MHC locus has _ alleles in an individual

Answer 1

2

Question 2

MHC molecules have _ major different classes, and each class contains ___________ loci

Answer 2

2
Different

Question 3

MHC is poly - ________ and poly- _________

Answer 3

Poly- GENIC
Poly- MORPHIC

Question 4

What is the combination of alleles on the same chromosome?

Answer 4

MHC Haplotype

Question 5

What do polygyny and polymorphism contribute to an individual?

Answer 5

MHC diversity

Question 6

Since MHC molecules bind to peptides through _________ _______, although having a limited number of MHC molecules, and individual can mount an _________ __________ against most invaders such as bacteria

Answer 6

Anchor residues
Immune response

Question 7

___________ MHC 1 and 2 molecules are highly polymorphic in a population

Answer 7

Classical

Question 8

MHC polymorphism in a population protects a species from being ___________

Answer 8

Eliminated

Question 9

______________ MHC 1 molecules display similar structure but are _______ polymorphic in a population

Answer 9

Nonclassical
Less

Question 10

What type of mutation simply changes in individual nucleotides?

Answer 10

Point

Question 11

What is it called when small blocks of DNA are exchanged between different class 1 genes in a non reciprocal fashion?

Answer 11

Gene conversion

Question 12

MHC/peptide complexes are not only _________ antigenic peptides to mature _ cells, but also determine T cell repertoire

Answer 12

Present
T

Question 13

What percent of positive selection occurs in thymus?

Answer 13

3%

Question 14

What percent of negative selection occurs in thymus?

Answer 14

7%

Question 15

What percent of death due to neglect occurs in thymus?

Answer 15

90%

Question 16

The more MHC molecules = the _________ the chance of the presentation of self-antigens

Answer 16

Higher

Question 17

The higher the chances of the presentation of self-antigens, the _________ the peripheral T cell repertoire

Answer 17

Smaller

Question 18

The higher the chances of the presentation of self-antigens, the ________ the chances of autoimmune diseases

Answer 18

Higher

Question 19

What is the consequence of the balance between the resistance of infection and the risk of autoimmunity in an individual?

Answer 19

MHC diversity

Question 20

How many different MHC la molecules appears to be a reasonable comprise between maximizing the recognition of foreign antigens while at the same time minimizing he chances of recognizing self-antigens, at least in humans?

Answer 20

6

Question 21

The presence of certain ____ alleles is associated with human disease

Answer 21

HLA

Question 22

What does DR4 and DQ8 make humans susceptible to?

Answer 22

Type 1 diabetes

Question 23

What does B57 and B27 make humans susceptible to?

Answer 23

Psoriasis
Ankylosing spondlytitis
Reiters Syndrome

Question 24

What is B57 and B27 over represented in?

Answer 24

HIV elite controllers

Question 25

Transplantation rejection is due to immune responses to?

Answer 25

Allogeneic MHC molecules

Question 26

Cattle has BoLA-DRB3.2*10 and is infected with bovine leukemia virus, you expect the cattle will have ________ pro viral load

Answer 26

High

Question 27

What are the 2 mechanisms for MHC polymorphism?

Answer 27

Gene conversion
Point mutation

Question 28

If a cow has BoLA-DRB3.23,7,8,11, *22, *24, *28 alleles, it has ____ proviral loads

Answer 28

Low

Question 29

What 2 properties make it difficult for pathogens to evade immune responses in a species?

Answer 29

Polygenic and Polymorphic