Complement System- Consequences

Question 1

What are the 3 major consequences of the complement activation?

Answer 1

Direct killing of pathogens
Promote phagocytosis of pathogens
Promote inflammation

Question 2

What is a substance which binds to foreign pathogens making them more susceptible to phagocytosis?

Answer 2

Opsonin

Question 3

What requires C5a, serves as an opsonin and opsonizes pathogens to enhance their phagocytosis?

Answer 3

C3b

Question 4

What increases vascular permeability?

Answer 4

Inflammation

Question 5

What increases infiltration of inflammatory cells in tissues?

Answer 5

Inflammation

Question 6

What 3 things are located within the major histocompatibility complex 3 region?

Answer 6

C4, C2, and factor B

Question 7

Where are the C4BP, CD55, CD35, CD21, CD46, and factor H linked within?

Answer 7

The regulation of complement activation (RCA) cluster

Question 8

What do complement components show in a population?

Answer 8

Multiple genetic variations

Question 9

What represents the pattern of genetic variants in complement genes inherited by an individual?

Answer 9

Complotype

Question 10

What to the complotypes influence?

Answer 10

An animals susceptibility to infections and inflammatory diseases

Question 11

What allele expression is associated with low serum C4 levels, and the development of autoimmune poly arthritis in dogs?

Answer 11

C4-4

Question 12

What is produced from a deletion of a single cytosine that leads to a frameshift and the generation of a premature stop codon?

Answer 12

Shortened C3 chain

Question 13

What breed of dog is autosomal hereditary recessive C3 deficiency commonly seen in?

Answer 13

Brittany Spaniels

Question 14

Dogs that are ________________ for the C3 deficiency trait have no detectable levels of C3, whereas _______________ animals have C3 levels that are approximately half normal

Answer 14

Homozygous
Heterozygous

Question 15

How do heterozygous animals for C3 present?

Answer 15

Clinically normal

Question 16

How do homozygous deficient animals present?

Answer 16

Increased susceptibility to bacterial infections

Question 17

What breed of pig is the porcine factor H deficiency seen in?

Answer 17

Yorkshire

Question 18

What type of trait is porcine factor H deficiency?

Answer 18

Autosomal recessive

Question 19

_________________ deficiency are almost totally deficient in factor H, whereas _______________ have half the normal levels

Answer 19

Homozygous
Heterozygous

Question 20

What deficiency in pigs is the following:
Affected piglets are healthy at birth and develop normal for a few weeks
They eventually fail to thrive, stop growing, become anemic, and die of renal failure

Answer 20

Porcine factor H deficiency

Question 21

What deficiency has the following:
Been described in children, causes increased susceptibility to infection
Not yet described in animals

Answer 21

MBL deficiency

Question 22

Congenital deficiencies of other complement components in lab animals or humans are not necessarily ______

Answer 22

Lethal

Question 23

Individuals with C6 or C7 deficient have been described as ?

Answer 23

Quite healthy

Question 24

Terminal complex formation may not be biologically ____________

Answer 24

Essential