13: NSAID Flashcards
What are NSAIDs
Non steroidal antiinflamatory drugs
Analgesic
Antipyretic
Cox-1
Constitutive membrane bound enzyme
Gatroprotective
Renal protective
Hemostasis
Cox-2
Bad
Inhibitors of cox2 Lower incidence of GI problems in humans
Produced in response to things
Adverse effects of NSAIDs
Dose/time related
Gastropathy
Acute renal failure (nephrotoxicity)
Idiosyncratic reactions
Major risk factors with canine treatment
Osteoarthritis
Postoperative
Chemical properties of NSAIDs
Well absorbed orally
Biphasic absorption in ruminates
Bound to food constituents
Pk properties of NSAIDs
High protein binding
Therapeutic effect persists after plasma levels have diminished
Penetration into milk is low
Limited renal elimination
Carprofin
Non selective
No cats!
Adverse effects: renal, GI
Ketoprofin
Approved in horses
No selectivity
GI/renal issues
If it ends in ib
Cox 2 selective
Deracoxib
Cox 2
Used for post op pain
Approved in dogs
Watch for sulfide sensitivity
Flunixin meglumine
Not selective
Has withdrawl times in food animals
Phenylbutazone
Do not give to animals intended for food consumption
Tepoxalin
Inhibit both coxs
Approved in dogs
