13: NSAID

Question 1

What are NSAIDs

Answer 1

Non steroidal antiinflamatory drugs
Analgesic
Antipyretic

Question 2

Cox-1

Answer 2

Constitutive membrane bound enzyme
Gatroprotective
Renal protective
Hemostasis

Question 3

Cox-2

Answer 3

Bad
Inhibitors of cox2 Lower incidence of GI problems in humans
Produced in response to things

Question 4

Adverse effects of NSAIDs

Answer 4

Dose/time related
Gastropathy
Acute renal failure (nephrotoxicity)
Idiosyncratic reactions

Question 5

Major risk factors with canine treatment

Answer 5

Osteoarthritis

Postoperative

Question 6

Chemical properties of NSAIDs

Answer 6

Well absorbed orally
Biphasic absorption in ruminates
Bound to food constituents

Question 7

Pk properties of NSAIDs

Answer 7

High protein binding
Therapeutic effect persists after plasma levels have diminished
Penetration into milk is low
Limited renal elimination

Question 8

Carprofin

Answer 8

Non selective
No cats!
Adverse effects: renal, GI

Question 9

Ketoprofin

Answer 9

Approved in horses
No selectivity
GI/renal issues

Question 10

If it ends in ib

Answer 10

Cox 2 selective

Question 11

Deracoxib

Answer 11

Cox 2
Used for post op pain
Approved in dogs
Watch for sulfide sensitivity

Question 12

Flunixin meglumine

Answer 12

Not selective

Has withdrawl times in food animals

Question 13

Phenylbutazone

Answer 13

Do not give to animals intended for food consumption

Question 14

Tepoxalin

Answer 14

Inhibit both coxs

Approved in dogs