13: NSAID Flashcards Preview

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Flashcards in 13: NSAID Deck (14)
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1
Q

What are NSAIDs

A

Non steroidal antiinflamatory drugs
Analgesic
Antipyretic

2
Q

Cox-1

A

Constitutive membrane bound enzyme
Gatroprotective
Renal protective
Hemostasis

3
Q

Cox-2

A

Bad
Inhibitors of cox2 Lower incidence of GI problems in humans
Produced in response to things

4
Q

Adverse effects of NSAIDs

A

Dose/time related
Gastropathy
Acute renal failure (nephrotoxicity)
Idiosyncratic reactions

5
Q

Major risk factors with canine treatment

A

Osteoarthritis

Postoperative

6
Q

Chemical properties of NSAIDs

A

Well absorbed orally
Biphasic absorption in ruminates
Bound to food constituents

7
Q

Pk properties of NSAIDs

A

High protein binding
Therapeutic effect persists after plasma levels have diminished
Penetration into milk is low
Limited renal elimination

8
Q

Carprofin

A

Non selective
No cats!
Adverse effects: renal, GI

9
Q

Ketoprofin

A

Approved in horses
No selectivity
GI/renal issues

10
Q

If it ends in ib

A

Cox 2 selective

11
Q

Deracoxib

A

Cox 2
Used for post op pain
Approved in dogs
Watch for sulfide sensitivity

12
Q

Flunixin meglumine

A

Not selective

Has withdrawl times in food animals

13
Q

Phenylbutazone

A

Do not give to animals intended for food consumption

14
Q

Tepoxalin

A

Inhibit both coxs

Approved in dogs