9 - Adrenergic Agents

Question 1

Adrenegic agents

Answer 1

Drugs that mimic or enhance actions of EP or NE

Question 2

Direct acting agents

Answer 2

Activate adrenegic recptores

Question 3

Indirect acting agents

Answer 3

No direct receptor actions
CAT inhibitors
monamine oxidase inhibitors

Question 4

Adrenolitic agents

Answer 4

Block NE/EP actions

Question 5

Chemical properties of catecholamines

Answer 5

Catechol ring

Oxidized in room air

Question 6

Catecholamine drugs

Answer 6

Dopamine
Norepi.
Epin.
Isoproterenol

Question 7

Properties of catecholamines

Answer 7

Not well absorbed
Rapid onset
Short duration
Enzymatic degradation

Question 8

Two families of adrenegic receptors

Answer 8

Alpha

Beta

Question 9

What receptors does Epi have a stronger action on

Answer 9

Beta

Question 10

Norepi has stronger action on what receptors

Answer 10

Alpha

Question 11

Where are alpha receptors located

Answer 11

Visceral organs

CNS

Question 12

A1 effects

Answer 12

Increased PI formation

Question 13

A2 effects

Answer 13

Decreased cAMP formation

Question 14

Phenylephrine receptors

Answer 14

Alpha agonist

Question 15

Beta receptor effects

Answer 15

Increase cAMP

Question 16

Beta 1/2 agonist

Answer 16

Isoproterenol

Question 17

What mediates EP and NE effects

Answer 17

B1 receptors in cardiac tissues

Question 18

What effect do Symp drugs have on the heart

Answer 18

Increase: rate, contractility, conduction velocity

Question 19

How do B1 receptors work

Answer 19

Via G protien mediated activation of adrenal cyclist with increased production of intracellular cAMP

Question 20

Target of Symp stimulation on blood vessels

Answer 20

Vascular smooth muscle cell

Question 21

Sympathetic effect on blood vessels

Answer 21

Pressor response
Increase mean arterial pressure
opposing actions by B and A receptors

Question 22

A1 receptor on blood vessel

Answer 22

Increase blood receptor

Constriction

Question 23

B2 receptor on blood vessels

Answer 23

Dilation

Question 24

Cardiovascular actions of NE depend on

Answer 24

What receptor

Question 25

A1 stimulation NE

Answer 25

Increased: systolic, diastolic, and mean arterial pressures Decreased: Heart rate

Question 26

Why does NE stimulation with a1 receptor cause a decrease in HR

Answer 26

Barroreceptors

Question 27

Isoproterenol works on what receptors

Answer 27

Beta

Question 28

Effect of Isoproterenol on B2

Answer 28

Decrease: blood pressure vasodilation Increase: heart rate, cardiac output

Question 29

EP acts on

Answer 29

A2 and B1&2 receptors

Question 30

EP low dose

Answer 30

B2: Vasodilation B1: increase HR., cardiac output

Question 31

EP high dose

Answer 31

B1: Increase HR (can cause arrhythmia) B1 & A1: systolic vasoconstriction A1: diastolic vasoconstriction

Question 32

Eye a1 agonist

Answer 32

Pupil dilation

Question 33

Lungs B2 agonists

Answer 33

Enhanced secretion Relaxation Used in inhalers

Question 34

Lungs a1 agonist

Answer 34

Reduced secretion (predominates)

Question 35

GI B1

Answer 35

Reduce motility

Question 36

GI a1

Answer 36

Constrict sphincter

Question 37

Bladder b1

Answer 37

Relax fundis

Question 38

Bladder a1

Answer 38

Constict sphincter

Question 39

Sweat glands

Answer 39

Goofy as shit

Question 40

Uses of alpha adrenegic agonists

Answer 40

Maintain blood pressure Reduce localized bleeding Nasal decongestants Emetic effect in cats

Question 41

Phenylephrine

Answer 41

Increase BP Acute pressor -Management of shock Stimulates a1&2

Question 42

Phenylephrine adverse effects

Answer 42

Bradycardia Excitation/nervous PE + atropine = increased BP and tachycardia Extravasation injury

Question 43

A adrenegic antagonists uses

Answer 43

acute reduction in BP Urinary tract disorders (relaxes) Reversal of Xylazine induced depression

Question 44

Side effects of alpha blocker

Answer 44

``` Postural hypotension GI irritability Stuffiness Impotence Sedation and depression ```

Question 45

A- adrenergic antagonists

Answer 45

Phentolamine Phenoxybenzamine Yohimbine Atipamezole

Question 46

Use of B adrenergic agonists

Answer 46

``` B1: Acute treatment of cardiac failure B2: Respiratory difficulty and bronchial asthma -short term Delay parturition B1/2: allergic reactions ```

Question 47

Uses for a adrenergic agonists

Answer 47

Hemostasis Nasal decongestant Raise BP Adjuncts to local anesthetics

Question 48

Isoproterenol

Answer 48

B1/2 | Cardiac stimulation

Question 49

Terbutaline

Answer 49

B2 Treat asthma No stimulation of heart

Question 50

B adrenergic agonists uses

Answer 50

Increase: HR, Cardiac contraction Conduction through AV node (B1) Smooth muscle relaxation (B2)

Question 51

What does the magnitude of effects produced by adrenegic drugs depend on

Answer 51

Sympathetic activity

Question 52

Primary use for B antagonists

Answer 52

Cardiac effects Long term control of systemic hypertension Anti arrhythmic Heart failure

Question 53

Propranolol

Answer 53

B1/2 Antiarrhythmic Must be withdrawn gradually IV

Question 54

Atenolol

Answer 54

B1 blocker Anti arrhythmic

Question 55

Esmolol

Answer 55

B1 blocker