Tranquilizer
low dose calm
high dose sedate
sedative
depress behavior and diminish excitability without sleep
hypnotic
light sleep the animal can be aroused from
narcotic
animal cant be easily aroused
anesthetic
deep sleep no sensation
What do all CNS depressants have in common
capacity to produce additive or synergistic effects with other CNS depressants
2 CNS depression pathways
Ketamine
Diazepam
Ketamine
antagonism of the excitatory neurotransmitter GLU
Not a barbiturate
anesthetic
Diazepam
sedative-tranquilizer
benzodiazepine
enhance inhibition of GABA
Monoamines
do not cross BBB
can act as peripheral transmitters or only in CNS
Catecholamines
excitatory transmitters
may activate or inhibit receptors
May inhibit CA elimination process
drugs that inhibit CNS catecholamine
depress CNS function
Drugs that enhance CNS catecholamines
facilitate CNS function
