3- Cellular Processes For Drug Absorption Flashcards Preview

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Flashcards in 3- Cellular Processes For Drug Absorption Deck (17)
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1
Q

ADME

A

Absorption
Distribution
Metabolism
Elimination

2
Q

Absorption

A

Measure of the rate and amount of drug that moves from administration site into the bloodstream

3
Q

Bioavailability (F)

A

Fraction of drug that passes into the blood stream

For any administration, F is measured relative to the IV admin for the same drug

4
Q

Formula for bioavailability (F)

A

F= AUC (non-IV type of admin)/ AUC (admin by IV) X 100%

5
Q

If bioavailability = 60% what does that mean

A

60% of drug makes it to the blood stream

6
Q

Determinants of drug absorption

A

Drug solubility
Drug concentration
Local blood flow

7
Q

What is the major driving force for drugs to move into the vasculature

A

Concentration Gradient

8
Q

Characteristics of blood flow as absorption

A

Can vary because of environment, fear level, exercise, IM vs SC
Can be the rate limiting step

9
Q

What is the most common mechanism for drugs to pass through cell membranes

A

Passive diffusion

10
Q

How does charge affect how fast drugs pass through barriers

A

Charged drugs move slower

11
Q

Calculation of amount of drug delivered to a tissue

A

Drug delivery= concentration(plasma drug conc) X volume (blood flow)

12
Q

What two factors affect drug distribution

A

amount of drug delivered to a tissue

Rate of passage through vascular wall

13
Q

For highly lipophlic drugs what does distribution depend exclusively on

A

Tissue blood flow

14
Q

Characteristics of plasma protein binding

A

Decrease apparent vol of distribution
Decrease intensity of clinical effects
Inc. Drug half life in plasma
Inc. incidence of drug interactions

15
Q

Is drug-protein binding reversible

A

Yes

16
Q

Is the degree of drug-protein binding a fixed constant

A

No

17
Q

What is a source of clinically significant drug-protein interactions

A

May compete for binding sites and cause mutual displacement