Type 1 Hypersensitivity

Question 1

Some medicines can be allergenic. Why?

Answer 1

• Full antigens (eg therapeutic proteins)
• OR react with endogenous proteins to become antigenic

Question 2

Interactions of allergen with epithelial cells activate? examples of mediators that can do this?

Answer 2

Innate immunity

Mediators such as granulocyte macrophage- CSF are released

Question 3

IL-C2 lymphocyte is?

Answer 3

Specialised type of white blood Cell

Question 4

IL-C2s are important in activating innate immunity. Why?

Answer 4

Release other mediators which stimulate production and recruitment of eosinophils

Question 5

Allergic sensitisation: APCs release mediators which enable them to interact with specialised T-cells to develop into?

Answer 5

Specialised T- cells which develop into Th2 lymphocytes

Question 6

Allergic sensitisation: activation of Th2 cells enables their interaction with?

Answer 6

B-lymphocytes and class switching of B cells to produce IgE

Question 7

Allergic sensitisation: when IgE is combined to receptors on basophils and mast cells this has what effect?

Answer 7

Desensitises them for future encounters with the allergen

Question 8

Allergic sensitisation: 1 step is interplay of innate and acquired immunity. Give steps

Answer 8

Interaction of allergen with epithelial cells —> activates innate immunity
Mediators are involved
Activated IL-C2s
Activation of TH2
IgE desensitises basophils and mast cells