Endo Pharm

Question 1

Prolactinoma causes what clinical signs and symptoms

Answer 1

Women: amenorrhea, infertility, galactorrhea
Men: Infertility, loss of libido, impotence

Question 2

What are the dopamine receptor agonists used to treat Prolactin excess

Answer 2

Bromocriptine: poorly tolerated D2 receptor agonist
Cabergoline: High affinity D2 receptor agonist

Question 3

How do you test for GH deficiency?

Answer 3

With insulin. GH release is stimulated by hypoglycemia. Give insulin to drive down blood sugar and see if GH rises.

Question 4

Human Growth Hormone treatment in kids is most effective in what time period?

Answer 4

First two years. Treat until growth stops

Question 5

Generic hGH is

Answer 5

Somatotropin

Question 6

Somatrem is what

Answer 6

GH with additional methionin

Question 7

Semorelin Acetate?

Answer 7

first 29 aa of hGHRH

Question 8

Adverse effects of Grwoth hormone replacement in kids

Answer 8

Intracranial HTN, papilledema, visual problems, Leukemia

Question 9

Leading cause of retardation worldwide is?

Answer 9

Hypothyroidism

Question 10

Thyroid hormone has what effect on oxygen consumption?

Answer 10

Increases it

Question 11

Thyroid has what effect on CV system

Answer 11

upregulates Beta1 receptors on the heart. Increased HR and strength of contraction (inotrophy)

Question 12

Describe the pathophysiology of Iodine deficiency

Answer 12

Iodine deficiency results in low productin of thyroid hormones. TSH levels increase to try to correct this and you get hypertrophy of the thyroid gland

Question 13

Treat iodine deficiency with

Answer 13

iodized salt

Question 14

How do you treat hypothyroidism

Answer 14

replacement therapy

Question 15

Levothyroxine

Answer 15

L-T4…levFOthyroxine

Question 16

Liothyronine sodium

Answer 16

L-T3

Question 17

Liotrix

Answer 17

mixture of T4 and T3

Question 18

Treat hyperthyroidism with what type of drugs?

Answer 18

Thioureylenes (they inhibit thyroid peroxidase, the enzyme responsible for virtually all of thyroid synthesis)

Question 19

PTU= Propylthiouracil

Answer 19

Inhibits thyroid peroxidase, but also inhibits thyronine 5’ deiodinase (5’/3’ deiodinase which is responsible for T4 to T3 conversion).

Question 20

Which hyperthyroid drug is preferred in pregnant patients

Answer 20

polythiouracil. less placental/ milk transfer

Question 21

AE’s of polythiouracil

Answer 21

rash and agranulocytosis

Question 22

Methimazole?

Answer 22

way more potent than polythiouracil and longer half life. Crosses placenta and gets concentrated in fetal thyroid