Testicular Disease

Question 1

Testicular peptide hormones are

Answer 1

Follistatin, activins, inhibins

Question 2

What does follistatin do?

Answer 2

Inactivates both activins and inhibins

Question 3

Activins are produced where and do what?

Answer 3

Sertoli cells, stimulate FSH beta0-subunit production

Question 4

Inhibins?

Answer 4

Produced in the seminiferous tubules, suppress FSH

Question 5

What happens if the seminiferous tubules are injured?

Answer 5

FSH goes up

Question 6

Hypothalamic dysfunction

Answer 6

low GnRH leads to low LH and FSH

Question 7

Pituitary disorders

Answer 7

Low LH and or FSH production

Question 8

Gonadal disorders

Answer 8

failure of testosterone production from Leydig Cells and/or spermatogenesis. LH and FSH will be elevated if there is no feedback

Question 9

Post gonadal disorder

Answer 9

defects in testosterone receptor function

Question 10

Normal LH and FSH in the face of low T +

Answer 10

pathologic

Question 11

Fertile Eunuch syndrome =

Answer 11

LH deficiency

Question 12

What happens if you are LH deficient?

Answer 12

no T

Question 13

Hyperprolactinemia

Answer 13

Prolactin drives down GnRH so no LH and FSH

Question 14

Hemochromatosis

Answer 14

iron in pituitary and testes

Question 15

Klinefelter’s syndrome

Answer 15

xxy, tall, gynecomastia, eunuchoid, Mental retardation

Question 16

body never exposed to testosterone

Answer 16

no secondary sex characteristics

Question 17

Pre-pubertal gonadal failure

Answer 17

small dick, balls, prostate
delayed puberty
long arms and legs
reduced musculaturehigh pitched voice

Question 18

post pubertal

Answer 18

progressive decrease in muscle mass
loss of libido
impotence
infertilitypoor ability to concentrate
hot flashes

Question 19

LH and FSH are released in what fashion

Answer 19

pulsatile

Question 20

If you dont release LH and FSH in a pulsatile fashion they have the opposite effect

Answer 20

truth

Question 21

What’s weird about prolactin

Answer 21

It is always being made unless dopaminergic signaling tells it to stop

Question 22

What does prolactin do to LH and FSH

Answer 22

turns it off

Question 23

What is Kollman’s syndrome?

Answer 23

failure to enter puberty and anosmia (can’t smell). Normal LH and FSH with low T

Question 24

Prader willi

Answer 24

Hyperphagia with obesity, micropenis, small hands and feet

Question 25

Lawrence Moon

Answer 25

Retinitis Pigementosa and polydactyly

Question 26

Soft testes? Haven’t seen LH and FSH in a while

Answer 26

ok