Therapeutic Cytapheresis- pxt with blood disorder

Question 1

What is the outcome of performing Plateletpheresis as part of Therapeutic Cytapheresis for a patient with a blood disorder?

Answer 1

> Plateletpheresis an equivalent result to receiving 6-10 random platelet concentrates.

Question 2

Give the Contents of Platetletpheresis

Answer 2

> 3 x 1011 platelets

Question 3

What are the therapeutic indications of plateletpheresis?

Answer 3

> Used to treat patients who have abnormally elevated platelet counts (plt. ct. >1,000,000/uL) such as in the case of Polycythemia vera

Question 4

What is the purpose of using HES (Hydroxyethyl starch) in leukapheresis?

Answer 4

• Used as a sedimenting agent during leukapheresis to enhance granulocyte collection.
• It promotes the formation of rouleaux, causing red cells to clump together, which enables more efficient harvesting of white blood cells (WBCs)

Question 5

Why are corticosteroids administered to donors before leukapheresis?

Answer 5

• Are given to donors 12-24 hours prior to leukapheresis to increase the number of circulating granulocytes.
• These drugs help pull granulocytes from the marginal pool.

Question 6

What are the therapeutic indications of Leukapheresis?

Answer 6

> Used to treat patients with leukemia (wbc>100,000/uL) such as Hairy cell
leukemia, AML, Cutaneous T cell lymphoma

Question 7

What are the therapeutic indications of Lymphocytapheresis?

Answer 7

> Means of producing immunosuppression in conditions like RA, SLE, Kidney
transplant rejection and autoimmune and alloimmunedses.

Question 8

What is Neocytapheresis, and what does it involve?

Answer 8

> Neocytapheresis is a medical procedure involving the transfusion of young red blood cells (neocytes).

Question 9

What are the therapeutic indications of Neocytapheresis?

Answer 9

> for young pxs with certain hematologic disorders especially thalassemia Syndromes

Question 10

What is erythrocytapheresis?

Answer 10

• An exchange procedure in which a predetermined quantity of red blood cells is removed from the patient and replaced with compatible donor blood.

Question 11

What are the therapeutic indications of Erythrocytapheresis?

Answer 11

> Used to treat various complications of Sickle cell disease, such as priapism and
impending stroke

Question 12

Under Erythrocytapheresis, In PXS with severe parasitic infections from ___________.

Answer 12

> Malaria and Babesia

Question 13

Enumerate the 5 THERAPEUTIC CYTAPHERESIS

Answer 13

1. Platetletpheresis
2. Leukapheresis
3. Lymphocytapheresis
4. Neocytapheresis
5. Erythrocytapheresis